From: Pharmacokinetic characteristics and anticancer effects of 5-Fluorouracil loaded nanoparticles
LoVo cell xenografts | Tca8113 cell xenografts | |||||
---|---|---|---|---|---|---|
TDT (d) | IR (%) | TV(cm3) | TDT (d) | IR (%) | TV(cm3) | |
Blank control | 3.0 | 0 | 4.336 ± 0.485 | 3.5 | 0 | 3.888 ± 0.547 |
PEG-PBLG | 2.9 | 0 | 4.206 ± 0.308* | 3.6 | 0 | 3.944 ± 0.179* |
5-FU | 4.08 | 62.2% | 1.637 ± 0.330# | 4.6 | 65.4% | 1.346 ± 0.142# |
5-FU/PEG-PBLG | 4.50 | 77.1% | 0.993 ± 0.122#§ | 5.3 | 89.6% | 0.405 ± 0.174#§ |