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Table 2 The anticancer effect of 5-FU/PEG-PBLG nanoparticles

From: Pharmacokinetic characteristics and anticancer effects of 5-Fluorouracil loaded nanoparticles

  LoVo cell xenografts Tca8113 cell xenografts
  TDT (d) IR (%) TV(cm3) TDT (d) IR (%) TV(cm3)
Blank control 3.0 0 4.336 ± 0.485 3.5 0 3.888 ± 0.547
PEG-PBLG 2.9 0 4.206 ± 0.308* 3.6 0 3.944 ± 0.179*
5-FU 4.08 62.2% 1.637 ± 0.330# 4.6 65.4% 1.346 ± 0.142#
5-FU/PEG-PBLG 4.50 77.1% 0.993 ± 0.122 5.3 89.6% 0.405 ± 0.174
  1. TDT, tumor doubling time; IR, inhibition rate; TV, tumor volume at day 21 for LoVo cell xenografts and at day 34 for Tca 8113 cell xenografts.
  2. *compared with blank control, p > 0.05.
  3. #compared with blank control, p < 0.01,
  4. §compared with 5-FU, p < 0.01.