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Table 2 The anticancer effect of 5-FU/PEG-PBLG nanoparticles

From: Pharmacokinetic characteristics and anticancer effects of 5-Fluorouracil loaded nanoparticles

 

LoVo cell xenografts

Tca8113 cell xenografts

 

TDT (d)

IR (%)

TV(cm3)

TDT (d)

IR (%)

TV(cm3)

Blank control

3.0

0

4.336 ± 0.485

3.5

0

3.888 ± 0.547

PEG-PBLG

2.9

0

4.206 ± 0.308*

3.6

0

3.944 ± 0.179*

5-FU

4.08

62.2%

1.637 ± 0.330#

4.6

65.4%

1.346 ± 0.142#

5-FU/PEG-PBLG

4.50

77.1%

0.993 ± 0.122

5.3

89.6%

0.405 ± 0.174

  1. TDT, tumor doubling time; IR, inhibition rate; TV, tumor volume at day 21 for LoVo cell xenografts and at day 34 for Tca 8113 cell xenografts.
  2. *compared with blank control, p > 0.05.
  3. #compared with blank control, p < 0.01,
  4. §compared with 5-FU, p < 0.01.