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Table 1 In vivo pharmacokinetic parameters of 5-FU and 5-FU/PEG-PBLG nanoparticles

From: Pharmacokinetic characteristics and anticancer effects of 5-Fluorouracil loaded nanoparticles

  t1/2(h) Cmax (μg/L) Tmax(h) Vd(L) AUC(μg · h/L)
5-FU 0.088 17047.3 0 0.069 6263.7
5-FU/PEG-PBLG 33.3 4563.5 1.25 0.114 5794.7
  1. t1/2, elimination half-life; Cmax, peak concentration; Tmax, peak time; AUC, area under the concentration-time curve; Vd, distribution volume.