Table 1 Clinicopathological characteristics of patient cohorts

Age

   median (range)

45 (29 – 68)

57 (38 – 85)

<0.0001

Age > 50 years

16 (33%)

82 (68%)

Histological type

   invasive ductal

42 (87%)

103 (85.8%)

0.7993

   invasive lobular

1 (2%)

10 (8.3%)

0.14

   medullary like

5 (10%)

0

< 0.001

   other

0

9 (7.5%)

< 0.001

Tumor grade

   I

1 (2.0%)

36 (29%)

<0.001

   II

11 (22.9%)

53 (44.1%)

0.0122

   III

27 (56.2%)

26 (21.7%)

<0.0001

   unknown

9 (18.7%)

5 (4.2%)

0.0017

Tumor size

   median

2.2

3.0

0.14

   ≤ 2 cm

28 (58.3%)

53 (44.1%)

0.102

   > 2 cm ≤ 5 cm

16 (33.3%)

50 (41.6%)

0.282

   > 5 cm

3 (6.2%)

17 (14.1%)

0.147

   unknown

1 (2.0%)

0

Lymph node

   negative

34 (70.8%)

52 (43.3%)

0.001

   positive ≤ 3

8 (16.6%)

38 (31.6%)

0.015

   positive >3

4 (8.3%)

22 (18.0%)

0.104

   unknown

2 (4.1%)

8 (6.6%)

Bilateral breast cancer

13 (27.1%)

2 (1.7%)

<0.0001

Mutation:

   5382insC

37 (77.5%)

   C61G

10 (20.4%)

   4153delA

1 (2%)