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Table 1 Clinicopathological characteristics of patient cohorts

From: Expression of estrogen receptor beta in the breast carcinoma of BRCA1 mutation carriers

Parameter BRCA1-associated breast cancers n = 48 Control group n = 120 P-value
Age    
   median (range) 45 (29 – 68) 57 (38 – 85) <0.0001
Age > 50 years 16 (33%) 82 (68%)  
Histological type    
   invasive ductal 42 (87%) 103 (85.8%) 0.7993
   invasive lobular 1 (2%) 10 (8.3%) 0.14
   medullary like 5 (10%) 0 < 0.001
   other 0 9 (7.5%) < 0.001
Tumor grade    
   I 1 (2.0%) 36 (29%) <0.001
   II 11 (22.9%) 53 (44.1%) 0.0122
   III 27 (56.2%) 26 (21.7%) <0.0001
   unknown 9 (18.7%) 5 (4.2%) 0.0017
Tumor size    
   median 2.2 3.0 0.14
   ≤ 2 cm 28 (58.3%) 53 (44.1%) 0.102
   > 2 cm ≤ 5 cm 16 (33.3%) 50 (41.6%) 0.282
   > 5 cm 3 (6.2%) 17 (14.1%) 0.147
   unknown 1 (2.0%) 0  
Lymph node    
   negative 34 (70.8%) 52 (43.3%) 0.001
   positive ≤ 3 8 (16.6%) 38 (31.6%) 0.015
   positive >3 4 (8.3%) 22 (18.0%) 0.104
   unknown 2 (4.1%) 8 (6.6%)  
Bilateral breast cancer 13 (27.1%) 2 (1.7%) <0.0001
Mutation:    
   5382insC 37 (77.5%)   
   C61G 10 (20.4%)   
   4153delA 1 (2%)