Table 2 Sequence alterations found by direct sequencing
From: Epidermal growth factor receptor structural alterations in gastric cancer
Alteration | Type | Frequency | References | |
|---|---|---|---|---|
Exon 18 | ||||
2184+19 G>A | Intronic variant | 2/77 | Ensembl SNP rs17337107 (dbSNP126) [17] | |
Exon 19 | ||||
2185-9 C>G | Intronic variant | 1/77 | Not yet described | |
2283+11 G>A | Intronic variant | 1/77 | Not yet described | |
2283+47 G>A | Intronic variant | 1/77 | Not yet described | |
2283+49 C>T | Intronic variant | 1/77 | Not yet described | |
Exon 20 | ||||
2284-60 C>T | Intronic variant | 2/77 | Ensembl SNP rs10241451 (dbSNP126) [17] | |
2300 C>T | Missense Ala 767 Val | 1/77 | Not yet described | |
2301 C>T | Silent Ala 767 Ala | 1/77 | Not yet described | |
2361G>A | Silent Gln 787 Gln | 43/77 | [16] | |
2415 C>T | Silent His 805 His | 1/77 | Not yet described | |
Exon 21 | ||||
2524 A>G | Missense Asn 842 Asp | 1/77 | Not yet described |