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Table 1 Clinical and hematological and Ky and FISH follow-up

From: Clonal evolution in a patient with CML detected by FISH precedes imatinib treatment failure

Sample Date Ky FISH Treatment & clinical condition
1 Jul/01 Only Ph Only Ph 35% Began IM 400 mg/d CHR
2 Nov/01 Ph plus double Ph Not enough material IM 400 mg/d CHR
3 Jan/02 No growth Only Ph 26% IM 400 mg/d CHR
4 Sep/02 Hipodiploid plus Ph Only Ph 22%
Clone BCR amplified without Ph 3%
Clone ABL amplified and Ph 5%
IM 400 mg/d Leucocytosis
5 Jun/03 Only Ph Only Ph = 28%
Clone BCR amplified without Ph = 1%
Clone ABL and/or BCR amplified with Ph = 28%
Clone ABL and/or BCR amplified and double Ph = 51%
Clone ABL and BCR amplified with triple Ph = 11%
Clone ABL lost with Ph = 5%
IM 600 mg/d
6 Nov/03 Ph plus lost Y, marker chromosome, trisomy chr 19, double Ph and trisomy chr 8. Only Ph = 4%
Clone ABL amplified without Ph = 1%
Clone ABL and/or BCR amplified with Ph = 18%
Clone ABL and/or BCR amplified with double Ph = 74%
Clone ABL and BCR amplified with triple PH = 1%
Trisomy chr 8 = 72%
IM 600 mg + Ara-C
7 Jul/04 No growth Only Ph = 44%
Clone ABL amplified with Ph = 6%
Clone ABL and/or BCR amplified with double Ph = 17%
IM 800 mg/d
sample Jan/ 05    Began with dasatinib
8 Dec/05 No growth Only Ph = 18% Dasatinib