From: Clonal evolution in a patient with CML detected by FISH precedes imatinib treatment failure
Sample | Date | Ky | FISH | Treatment & clinical condition |
---|---|---|---|---|
1 | Jul/01 | Only Ph | Only Ph 35% | Began IM 400 mg/d CHR |
2 | Nov/01 | Ph plus double Ph | Not enough material | IM 400 mg/d CHR |
3 | Jan/02 | No growth | Only Ph 26% | IM 400 mg/d CHR |
4 | Sep/02 | Hipodiploid plus Ph | Only Ph 22% Clone BCR amplified without Ph 3% Clone ABL amplified and Ph 5% | IM 400 mg/d Leucocytosis |
5 | Jun/03 | Only Ph | Only Ph = 28% Clone BCR amplified without Ph = 1% Clone ABL and/or BCR amplified with Ph = 28% Clone ABL and/or BCR amplified and double Ph = 51% Clone ABL and BCR amplified with triple Ph = 11% Clone ABL lost with Ph = 5% | IM 600 mg/d |
6 | Nov/03 | Ph plus lost Y, marker chromosome, trisomy chr 19, double Ph and trisomy chr 8. | Only Ph = 4% Clone ABL amplified without Ph = 1% Clone ABL and/or BCR amplified with Ph = 18% Clone ABL and/or BCR amplified with double Ph = 74% Clone ABL and BCR amplified with triple PH = 1% Trisomy chr 8 = 72% | IM 600 mg + Ara-C |
7 | Jul/04 | No growth | Only Ph = 44% Clone ABL amplified with Ph = 6% Clone ABL and/or BCR amplified with double Ph = 17% | IM 800 mg/d |
sample | Jan/ 05 | Began with dasatinib | ||
8 | Dec/05 | No growth | Only Ph = 18% | Dasatinib |