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Table 1 Clinical and hematological and Ky and FISH follow-up

From: Clonal evolution in a patient with CML detected by FISH precedes imatinib treatment failure

Sample

Date

Ky

FISH

Treatment & clinical condition

1

Jul/01

Only Ph

Only Ph 35%

Began IM 400 mg/d CHR

2

Nov/01

Ph plus double Ph

Not enough material

IM 400 mg/d CHR

3

Jan/02

No growth

Only Ph 26%

IM 400 mg/d CHR

4

Sep/02

Hipodiploid plus Ph

Only Ph 22%

Clone BCR amplified without Ph 3%

Clone ABL amplified and Ph 5%

IM 400 mg/d Leucocytosis

5

Jun/03

Only Ph

Only Ph = 28%

Clone BCR amplified without Ph = 1%

Clone ABL and/or BCR amplified with Ph = 28%

Clone ABL and/or BCR amplified and double Ph = 51%

Clone ABL and BCR amplified with triple Ph = 11%

Clone ABL lost with Ph = 5%

IM 600 mg/d

6

Nov/03

Ph plus lost Y, marker chromosome, trisomy chr 19, double Ph and trisomy chr 8.

Only Ph = 4%

Clone ABL amplified without Ph = 1%

Clone ABL and/or BCR amplified with Ph = 18%

Clone ABL and/or BCR amplified with double Ph = 74%

Clone ABL and BCR amplified with triple PH = 1%

Trisomy chr 8 = 72%

IM 600 mg + Ara-C

7

Jul/04

No growth

Only Ph = 44%

Clone ABL amplified with Ph = 6%

Clone ABL and/or BCR amplified with double Ph = 17%

IM 800 mg/d

sample

Jan/ 05

  

Began with dasatinib

8

Dec/05

No growth

Only Ph = 18%

Dasatinib