Table 1 The up-regulated genes by over 3-fold in the AOM/DSS group at wk 5

Plasminogen activator, tissue (Plat)

48.5

Wnt inhibitory factor 1 (Wif1)

48.5

Metallothionein 3 (Mt3)

11.3

Chloride channel calcium activated 1 /// chloride channel calcium activated 2 (Clca1 /// Clca2)

9.2

Nuclear factor, erythroid derived 2, like 3 (Nfe2l3)

7.5

Protein tyrosine phosphatase, receptor type, O (Ptpro)

7.5

Transient receptor potential cation channel, subfamily V, member 6 (Trpv6)

7

Chloride channel calcium activated 2 (Clca2)

7

Dual specificity phosphatase 4 (Dusp4)

5.7

Heat shock protein 1 (Hspb1)

5.7

Advillin (Avil)

5.3

Proprotein convertase subtilisin/kexin type 9 (Pcsk9)

4.9

Extracellular matrix protein 1 (Ecm1)

4.9

Bone morphogenetic protein 4 (Bmp4)

4.6

Insulin-like growth factor binding protein 3 (Igfbp3)

4.3

Axin2 (Axin2)

4.3

Transferring (Trf)

4.3

Caldesmon 1 (Cald1)

4.3

Guanylate nucleotide binding protein 2 (Gbp2)

4.3

Gap junction membrane channel protein alpha 1 (Gja1)

4.3

WASP family 1 (Wasf1)

4

Aspartoacylase (aminoacylase) 2 (Aspa)

4

Notch gene homolog 4 (Drosophila) (Notch4)

4

Matrix metalloproteinase 2 (Mmp2)

4

Actin, alpha 2, smooth muscle, aorta (Acta2)

4

Transgelin (Tagln)

4

Dermatopontin (Dpt)

4

Integrin alpha X (Itgax)

4

Hedgehog-interacting protein (Hhip)

4

Latent transforming growth factor beta binding protein 4 (Ltbp4)

4

Myeloid ecotropic viral integration site-related gene 1 (Mrg1)

3.7

Dachshund 1 (Drosophila) (Dach1)

3.7

Membrane targeting (tandem) C2 domain containing 1 (Mtac2d1)

3.7

Laminin B1 subunit 1 (Lamb1-1)

3.7

RAS-related C3 botulinum substrate 3 (Rac3)

3.7

Nitric oxide synthase 2, inducible, macrophage (Nos2)

3.6

Bone morphogenetic protein 5 (Bmp5)

3.5

Methylthioadenosine phosphorylase (Mtap)

3.5

Transcription factor 4 (Tcf4)

3.5

Transcription factor 21 (Tcf21)

3.5

CCAAT/enhancer binding protein (C/EBP), delta (Cebpd)

3.5

Apolipoprotein B editing complex 2 (Apobec2)

3.5

Microtubule associated serine/threonine kinase-like (Mastl)

3.5

Carboxypeptidase X 2 (M14 family) (Cpxm2)

3.5

Ubiquitin specific protease 18 (Usp18)

3.5

Procollagen, type VI, alpha 2 (Col6a2)

3.5

Chloride channel calcium activated 4 (Clca4)

3.5

Myosin, light polypeptide 9, regulatory (Myl9)

3.5

Small muscle protein, X-linked (Smpx)

3.5

Glutathione peroxidase 3 (Gpx3)

3.5

Septin 4 (4-Sep)

3.5

Cysteine rich protein 2 (Crip2)

3.5

Fibroblast growth factor 7 (Fgf7)

3.2

Proline arginine-rich end leucine-rich repeat (Prelp)

3.2

Expressed sequence AW125753 /// protein tyrosine phosphatase, receptor type, J (AW125753 /// Ptprj)

3.2

BTB (POZ) domain containing 11 (Btbd11)

3.2

Calpain 2 (Capn2)

3.2

Transglutaminase 2, C polypeptide (Tgm2)

3.2

Matrix metalloproteinase 14 (membrane-inserted) (Mmp14)

3.2

SEC8-like 1 (S. cerevisiae) (Sec8l1)

3.2

ADP-ribosylation factor 2 (Arf2)

3.2

Calponin 3, acidic (Cnn3)

3.2

Actin, gamma 2, smooth muscle, enteric (Actg2)

3.2

Stathmin 1 (Stmn1)

3.2

Chondroitin sulfate proteoglycan 2 (Cspg2)

3.2

DEP domain containing 1a (Depdc1a)

3.2

Inhibitor of DNA binding 2 (Idb2)

3.2

Pleckstrin homology-like domain, family A, member 1 (Phlda1)

3.2

Myelocytomatosis oncogene (Myc)

3

Stabilin 1 (Stab1)

3

Guanylate cyclase 1, soluble, beta 3 (Gucy1b3)

3

RNA binding motif, single stranded interacting protein 1 (Rbms1)

3

RAD51 associated protein 1 (Rad51ap1)

3

SRY-box containing gene 4 (Sox4)

3

T-box 3 (Tbx3)

3

Kruppel-like factor 7 (ubiquitous) (Klf7)

3

Bcl-2-related ovarian killer protein (Bok)

3

Estrogen-related receptor beta like 1 (Esrrbl1)

3

Complement component 3a receptor 1 (C3ar1)

3

Tropomyosin 2, beta (Tpm2)

3

Procollagen, type V, alpha 1 (Col5a1)

3

Integrin alpha 8 (Itga8)

3

Annexin A8 (Anxa8)

3

Podocalyxin-like (Podxl)

3

Retinol dehydrogenase 9 (Rdh9)

3

Tumor necrosis factor, alpha-induced protein 9 (Tnfaip9)

3