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Table 1 The up-regulated genes by over 3-fold in the AOM/DSS group at wk 5

From: Global gene expression analysis of the mouse colonic mucosa treated with azoxymethane and dextran sodium sulfate

Gene name (gene symbol) Average fold of change (AOM/DSS vs. untreated)
Plasminogen activator, tissue (Plat) 48.5
Wnt inhibitory factor 1 (Wif1) 48.5
Metallothionein 3 (Mt3) 11.3
Chloride channel calcium activated 1 /// chloride channel calcium activated 2 (Clca1 /// Clca2) 9.2
Nuclear factor, erythroid derived 2, like 3 (Nfe2l3) 7.5
Protein tyrosine phosphatase, receptor type, O (Ptpro) 7.5
Transient receptor potential cation channel, subfamily V, member 6 (Trpv6) 7
Chloride channel calcium activated 2 (Clca2) 7
Dual specificity phosphatase 4 (Dusp4) 5.7
Heat shock protein 1 (Hspb1) 5.7
Advillin (Avil) 5.3
Proprotein convertase subtilisin/kexin type 9 (Pcsk9) 4.9
Extracellular matrix protein 1 (Ecm1) 4.9
Bone morphogenetic protein 4 (Bmp4) 4.6
Insulin-like growth factor binding protein 3 (Igfbp3) 4.3
Axin2 (Axin2) 4.3
Transferring (Trf) 4.3
Caldesmon 1 (Cald1) 4.3
Guanylate nucleotide binding protein 2 (Gbp2) 4.3
Gap junction membrane channel protein alpha 1 (Gja1) 4.3
WASP family 1 (Wasf1) 4
Aspartoacylase (aminoacylase) 2 (Aspa) 4
Notch gene homolog 4 (Drosophila) (Notch4) 4
Matrix metalloproteinase 2 (Mmp2) 4
Actin, alpha 2, smooth muscle, aorta (Acta2) 4
Transgelin (Tagln) 4
Dermatopontin (Dpt) 4
Integrin alpha X (Itgax) 4
Hedgehog-interacting protein (Hhip) 4
Latent transforming growth factor beta binding protein 4 (Ltbp4) 4
Myeloid ecotropic viral integration site-related gene 1 (Mrg1) 3.7
Dachshund 1 (Drosophila) (Dach1) 3.7
Membrane targeting (tandem) C2 domain containing 1 (Mtac2d1) 3.7
Laminin B1 subunit 1 (Lamb1-1) 3.7
RAS-related C3 botulinum substrate 3 (Rac3) 3.7
Nitric oxide synthase 2, inducible, macrophage (Nos2) 3.6
Bone morphogenetic protein 5 (Bmp5) 3.5
Methylthioadenosine phosphorylase (Mtap) 3.5
Transcription factor 4 (Tcf4) 3.5
Transcription factor 21 (Tcf21) 3.5
CCAAT/enhancer binding protein (C/EBP), delta (Cebpd) 3.5
Apolipoprotein B editing complex 2 (Apobec2) 3.5
Microtubule associated serine/threonine kinase-like (Mastl) 3.5
Carboxypeptidase X 2 (M14 family) (Cpxm2) 3.5
Ubiquitin specific protease 18 (Usp18) 3.5
Procollagen, type VI, alpha 2 (Col6a2) 3.5
Chloride channel calcium activated 4 (Clca4) 3.5
Myosin, light polypeptide 9, regulatory (Myl9) 3.5
Small muscle protein, X-linked (Smpx) 3.5
Glutathione peroxidase 3 (Gpx3) 3.5
Septin 4 (4-Sep) 3.5
Cysteine rich protein 2 (Crip2) 3.5
Fibroblast growth factor 7 (Fgf7) 3.2
Proline arginine-rich end leucine-rich repeat (Prelp) 3.2
Expressed sequence AW125753 /// protein tyrosine phosphatase, receptor type, J (AW125753 /// Ptprj) 3.2
BTB (POZ) domain containing 11 (Btbd11) 3.2
Calpain 2 (Capn2) 3.2
Transglutaminase 2, C polypeptide (Tgm2) 3.2
Matrix metalloproteinase 14 (membrane-inserted) (Mmp14) 3.2
SEC8-like 1 (S. cerevisiae) (Sec8l1) 3.2
ADP-ribosylation factor 2 (Arf2) 3.2
Calponin 3, acidic (Cnn3) 3.2
Actin, gamma 2, smooth muscle, enteric (Actg2) 3.2
Stathmin 1 (Stmn1) 3.2
Chondroitin sulfate proteoglycan 2 (Cspg2) 3.2
DEP domain containing 1a (Depdc1a) 3.2
Inhibitor of DNA binding 2 (Idb2) 3.2
Pleckstrin homology-like domain, family A, member 1 (Phlda1) 3.2
Myelocytomatosis oncogene (Myc) 3
Stabilin 1 (Stab1) 3
Guanylate cyclase 1, soluble, beta 3 (Gucy1b3) 3
RNA binding motif, single stranded interacting protein 1 (Rbms1) 3
RAD51 associated protein 1 (Rad51ap1) 3
SRY-box containing gene 4 (Sox4) 3
T-box 3 (Tbx3) 3
Kruppel-like factor 7 (ubiquitous) (Klf7) 3
Bcl-2-related ovarian killer protein (Bok) 3
Estrogen-related receptor beta like 1 (Esrrbl1) 3
Complement component 3a receptor 1 (C3ar1) 3
Tropomyosin 2, beta (Tpm2) 3
Procollagen, type V, alpha 1 (Col5a1) 3
Integrin alpha 8 (Itga8) 3
Annexin A8 (Anxa8) 3
Podocalyxin-like (Podxl) 3
Retinol dehydrogenase 9 (Rdh9) 3
Tumor necrosis factor, alpha-induced protein 9 (Tnfaip9) 3