Skip to main content

Table 2 Frequency distributions of XPC genotypes and their associations with risk of lung cancer

From: Sequence variations in DNA repair gene XPCis associated with lung cancer risk in a Chinese population: a case-control study

    Histologic type   Histologic type
XPC genotypes Controls n (%) Cases n (%) Adenocarcinoma n (%) Squamous cell n (%) Small cell n (%) All Cases OR (95% C.I.) Adenocarcinoma OR (95% CI) Squamous cell OR (95% CI) Small cell OR (95% CI)
rs3731055          
   GG 512 (52.0) 541 (55.9) 247 (60.0) 174 (54.5) 24 (38.7) 1.00 1.00 1.00 1.00
   AG 404 (41.0) 366 (37.8) 141 (34.2) 126 (39.4) 31 (50.0) 0.83 (0.69–1.01) 0.71 (0.56–0.92)** 0.90 (0.68–1.20) 1.69 (0.97–2.96)
   AA 69 (7.0) 60 (6.3) 24 (5.8)* 20 (6.2) 7 (11.3) 0.76 (0.52–1.11) 0.67 (0.41–1.10) 0.83 (0.47–1.45) 2.44 (0.99–6.02)
   AG+AA 473 (48.0) 426 (44.1) 165 (40.0) 146 (45.5) 38 (61.3) 0.82 (0.68–0.99)* 0.71 (0.56–0.90)** 0.86 (0.66–1.13) 1.79 (1.05–3.07)*
   A MAFa 27.5% 25.1% 22.9%* 25.9% 36.2%*     
rs2607775          
   CC 925 (93.1) 913 (92.0) 390 (92.2) 306 (92.7) 58 (90.6) 1.00 1.00 1.00 1.00
   CG 65 (6.5) 77 (7.8) 31 (7.3) 24 (7.3) 6 (9.4) 1.16 (0.82–1.66) 1.06 (0.67–1.67) 1.08 (0.64–1.81) 1.16 (0.47–2.88)
   GG 4 (0.4) 2 (0.2) 2 (0.5) 0 (0.0) 0 (0.0) 0.78 (0.14–4.34) 1.60 (0.28–9.02) --- ---
   CG+GG 69 (6.9) 79 (8.0) 33 (7.8) 24 (7.3) 6 (9.4) 1.15 (0.81–1.62) 1.10 (0.71–1.72) 1.08 (0.64–1.81) 1.16 (0.47–2.88)
   G MAFa 3.7% 4.1% 4.1% 3.6% 4.7%     
rs2228000          
   CC 446 (45.1) 452 (45.5) 184 (43.3) 149 (44.9) 31 (48.4) 1.00 1.00 1.00 1.00
   CT 456 (46.1) 435 (43.8) 193 (45.4) 149 (44.9) 25 (39.1) 0.98 (0.81–1.19) 1.05 (0.82–1.35) 1.01 (0.77–1.34) 0.79 (0.46–1.38)
   TT 88 (8.8) 107 (10.7) 48 (11.3) 34 (10.2) 8 (12.5) 1.28 (0.93–1.77) 1.42 (0.95–2.13) 1.20 (0.75–1.92) 1.37 (0.59–3.14)
   CT+TT 544 (54.9) 542 (54.5) 241 (66.7) 183 (55.1) 33 (51.6) 1.03 (0.86–1.24) 1.11 (0.88–1.40) 1.04 (0.80–1.36) 0.88 (0.53–1.48)
   T MAFa 31.9% 32.6% 34.0% 32.7% 32.0%     
rs2228001          
   AA 404 (40.7) 390 (39.4) 163 (38.3) 129 (39.2) 30 (47.6) 1.00 1.00 1.00 1.00
   AC 465 (46.9) 459 (46.3) 198 (46.5) 153 (46.5) 28 (44.4) 1.01 (0.83–1.22) 1.03 (0.80–1.33) 1.04 (0.78–1.38) 0.80 (0.47–1.38)
   CC 123 (12.4) 142 (14.3) 65 (15.2) 47 (14.3) 5 (8.0) 1.17 (0.88–1.56) 1.31 (0.92–1.88) 1.14 (0.75–1.72) 0.53 (0.20–1.40)
   AC+CC 588 (59.3) 601 (60.6) 263 (61.7) 200 (60.8) 33 (52.8) 1.04 (0.87–1.25) 1.09 (0.86–1.38) 1.06 (0.81–1.39) 0.74 (0.44–1.25)
   C MAFa 35.8% 37.5% 38.5% 37.5% 30.1%     
rs3729587          
   CC 768 (82.3) 756 (80.8) 329 (82.4) 260 (84.1) 47 (81.0) 1.00 1.00 1.00 1.00
   CG 130 (14.0) 149 (15.9) 59 (14.8) 42 (13.3) 9 (15.5) 1.14 (0.88–1.48) 1.09 (0.77–1.53) 0.93 (0.62–1.38) 1.09 (0.52–2.32)
   GG 35 (3.7) 31 (3.3) 12 (2.8) 8 (2.6) 2 (3.5) 0.90 (0.54–1.50) 0.82 (0.41–1.61) 0.59 (0.26–1.33) 0.86 (0.20–3.78)
   CG+GG 165 (17.7) 180 (19.2) 71 (17.6) 50 (15.9) 11 (19.0) 1.09 (0.86–1.39) 1.03 (0.75–1.41) 0.85 (0.59–1.23) 1.04 (0.52–2.08)
   G MAFa 10.7% 11.3% 10.4% 9.3% 11.2%     
  1. a MAF: minor allele frequency
  2. *P < 0.05; **P < 0.01.