|  |  | Histologic type |  | Histologic type | ||||
---|---|---|---|---|---|---|---|---|---|
XPC genotypes | Controls n (%) | Cases n (%) | Adenocarcinoma n (%) | Squamous cell n (%) | Small cell n (%) | All Cases OR (95% C.I.) | Adenocarcinoma OR (95% CI) | Squamous cell OR (95% CI) | Small cell OR (95% CI) |
rs3731055 | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   GG | 512 (52.0) | 541 (55.9) | 247 (60.0) | 174 (54.5) | 24 (38.7) | 1.00 | 1.00 | 1.00 | 1.00 |
   AG | 404 (41.0) | 366 (37.8) | 141 (34.2) | 126 (39.4) | 31 (50.0) | 0.83 (0.69–1.01) | 0.71 (0.56–0.92)** | 0.90 (0.68–1.20) | 1.69 (0.97–2.96) |
   AA | 69 (7.0) | 60 (6.3) | 24 (5.8)* | 20 (6.2) | 7 (11.3) | 0.76 (0.52–1.11) | 0.67 (0.41–1.10) | 0.83 (0.47–1.45) | 2.44 (0.99–6.02) |
   AG+AA | 473 (48.0) | 426 (44.1) | 165 (40.0) | 146 (45.5) | 38 (61.3) | 0.82 (0.68–0.99)* | 0.71 (0.56–0.90)** | 0.86 (0.66–1.13) | 1.79 (1.05–3.07)* |
   A MAFa | 27.5% | 25.1% | 22.9%* | 25.9% | 36.2%* |  |  |  |  |
rs2607775 | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   CC | 925 (93.1) | 913 (92.0) | 390 (92.2) | 306 (92.7) | 58 (90.6) | 1.00 | 1.00 | 1.00 | 1.00 |
   CG | 65 (6.5) | 77 (7.8) | 31 (7.3) | 24 (7.3) | 6 (9.4) | 1.16 (0.82–1.66) | 1.06 (0.67–1.67) | 1.08 (0.64–1.81) | 1.16 (0.47–2.88) |
   GG | 4 (0.4) | 2 (0.2) | 2 (0.5) | 0 (0.0) | 0 (0.0) | 0.78 (0.14–4.34) | 1.60 (0.28–9.02) | --- | --- |
   CG+GG | 69 (6.9) | 79 (8.0) | 33 (7.8) | 24 (7.3) | 6 (9.4) | 1.15 (0.81–1.62) | 1.10 (0.71–1.72) | 1.08 (0.64–1.81) | 1.16 (0.47–2.88) |
   G MAFa | 3.7% | 4.1% | 4.1% | 3.6% | 4.7% |  |  |  |  |
rs2228000 | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   CC | 446 (45.1) | 452 (45.5) | 184 (43.3) | 149 (44.9) | 31 (48.4) | 1.00 | 1.00 | 1.00 | 1.00 |
   CT | 456 (46.1) | 435 (43.8) | 193 (45.4) | 149 (44.9) | 25 (39.1) | 0.98 (0.81–1.19) | 1.05 (0.82–1.35) | 1.01 (0.77–1.34) | 0.79 (0.46–1.38) |
   TT | 88 (8.8) | 107 (10.7) | 48 (11.3) | 34 (10.2) | 8 (12.5) | 1.28 (0.93–1.77) | 1.42 (0.95–2.13) | 1.20 (0.75–1.92) | 1.37 (0.59–3.14) |
   CT+TT | 544 (54.9) | 542 (54.5) | 241 (66.7) | 183 (55.1) | 33 (51.6) | 1.03 (0.86–1.24) | 1.11 (0.88–1.40) | 1.04 (0.80–1.36) | 0.88 (0.53–1.48) |
   T MAFa | 31.9% | 32.6% | 34.0% | 32.7% | 32.0% |  |  |  |  |
rs2228001 | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   AA | 404 (40.7) | 390 (39.4) | 163 (38.3) | 129 (39.2) | 30 (47.6) | 1.00 | 1.00 | 1.00 | 1.00 |
   AC | 465 (46.9) | 459 (46.3) | 198 (46.5) | 153 (46.5) | 28 (44.4) | 1.01 (0.83–1.22) | 1.03 (0.80–1.33) | 1.04 (0.78–1.38) | 0.80 (0.47–1.38) |
   CC | 123 (12.4) | 142 (14.3) | 65 (15.2) | 47 (14.3) | 5 (8.0) | 1.17 (0.88–1.56) | 1.31 (0.92–1.88) | 1.14 (0.75–1.72) | 0.53 (0.20–1.40) |
   AC+CC | 588 (59.3) | 601 (60.6) | 263 (61.7) | 200 (60.8) | 33 (52.8) | 1.04 (0.87–1.25) | 1.09 (0.86–1.38) | 1.06 (0.81–1.39) | 0.74 (0.44–1.25) |
   C MAFa | 35.8% | 37.5% | 38.5% | 37.5% | 30.1% |  |  |  |  |
rs3729587 | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   CC | 768 (82.3) | 756 (80.8) | 329 (82.4) | 260 (84.1) | 47 (81.0) | 1.00 | 1.00 | 1.00 | 1.00 |
   CG | 130 (14.0) | 149 (15.9) | 59 (14.8) | 42 (13.3) | 9 (15.5) | 1.14 (0.88–1.48) | 1.09 (0.77–1.53) | 0.93 (0.62–1.38) | 1.09 (0.52–2.32) |
   GG | 35 (3.7) | 31 (3.3) | 12 (2.8) | 8 (2.6) | 2 (3.5) | 0.90 (0.54–1.50) | 0.82 (0.41–1.61) | 0.59 (0.26–1.33) | 0.86 (0.20–3.78) |
   CG+GG | 165 (17.7) | 180 (19.2) | 71 (17.6) | 50 (15.9) | 11 (19.0) | 1.09 (0.86–1.39) | 1.03 (0.75–1.41) | 0.85 (0.59–1.23) | 1.04 (0.52–2.08) |
   G MAFa | 10.7% | 11.3% | 10.4% | 9.3% | 11.2% |  |  |  |  |