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Table 2 Effects of oleuropein aglycone on the sensitivity of SKBR3 cells to trastuzumab a

From: Olive oil's bitter principle reverses acquired autoresistance to trastuzumab (Herceptin™) in HER2-overexpressing breast cancer cells

Oleuropein aglycone (ÎĽM)

TRASTUZUMAB IC30(ÎĽg/ml)

Sensitization factor (x-fold)b

0

18

-

3.125

10

2

6.25

4.5

4

12.5

1.1

16

25

0.36

50

  1. a Data represent the cell viability effects upon simultaneous exposure of HER2-positive and trastuzumab-sensitive SKBR3 breast cancer cells to oleuropein aglycone and trastuzumab. Briefly, SKBR3 cells were incubated in serial dilutions of trastuzumab in the absence or presence of a given concentration of oleuropein aglycone. IC30 values are the concentrations of trastuzumab which decreased cell viability by 30%, measured by using a MTT assay as described in "Methods". Values are mean of three independent experiments carried out in triplicate.
  2. b Sensitization factors were obtained by dividing the IC30 value of trastuzumab as single agent by the IC30 values obtained when oleuropein aglycone was concomitantly supplemented.
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BMC Cancer

ISSN: 1471-2407

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