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Table 2 Effects of oleuropein aglycone on the sensitivity of SKBR3 cells to trastuzumab a

From: Olive oil's bitter principle reverses acquired autoresistance to trastuzumab (Herceptin™) in HER2-overexpressing breast cancer cells

Oleuropein aglycone (μM) TRASTUZUMAB IC30(μg/ml) Sensitization factor (x-fold)b
0 18 -
3.125 10 2
6.25 4.5 4
12.5 1.1 16
25 0.36 50
  1. a Data represent the cell viability effects upon simultaneous exposure of HER2-positive and trastuzumab-sensitive SKBR3 breast cancer cells to oleuropein aglycone and trastuzumab. Briefly, SKBR3 cells were incubated in serial dilutions of trastuzumab in the absence or presence of a given concentration of oleuropein aglycone. IC30 values are the concentrations of trastuzumab which decreased cell viability by 30%, measured by using a MTT assay as described in "Methods". Values are mean of three independent experiments carried out in triplicate.
  2. b Sensitization factors were obtained by dividing the IC30 value of trastuzumab as single agent by the IC30 values obtained when oleuropein aglycone was concomitantly supplemented.