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Table 1 Dose modifications according to hematological toxicity in previous cycle

From: Trial on Refinement of Early stage non-small cell lung cancer. Adjuvant chemotherapy with pemetrexed and cisplatin versus vinorelbine and cisplatin: The TREAT protocol

Platelets (× 109/L) Nadir ANC (× 109/L) Nadir Percent or previous dose (both drugs)
≥ 50 and ≥ 0.5 100 %
≥ 50 and < 0.5 75%
< 50 and Any 50%
Any and < 1.0 + fever of = 38.5°Ca 75%
Recurrence of CTC Grade 3 or 4 after 2 dose reductions Recurrence of CTC Grade 3 or 4 after 2 dose reductions Discontinue patient from study
  1. a these criteria meet the CTCAE version 3.0 (NCI 2003) definition of febrile neutropenia