Platelets (× 109/L) Nadir | ANC (× 109/L) Nadir | Percent or previous dose (both drugs) |
---|---|---|
≥ 50 and | ≥ 0.5 | 100 % |
≥ 50 and | < 0.5 | 75% |
< 50 and | Any | 50% |
Any and | < 1.0 + fever of = 38.5°Ca | 75% |
Recurrence of CTC Grade 3 or 4 after 2 dose reductions | Recurrence of CTC Grade 3 or 4 after 2 dose reductions | Discontinue patient from study |