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Table 1 Dose modifications according to hematological toxicity in previous cycle

From: Trial on Refinement of Early stage non-small cell lung cancer. Adjuvant chemotherapy with pemetrexed and cisplatin versus vinorelbine and cisplatin: The TREAT protocol

Platelets (× 109/L) Nadir

ANC (× 109/L) Nadir

Percent or previous dose (both drugs)

≥ 50 and

≥ 0.5

100 %

≥ 50 and

< 0.5

75%

< 50 and

Any

50%

Any and

< 1.0 + fever of = 38.5°Ca

75%

Recurrence of CTC Grade 3 or 4 after 2 dose reductions

Recurrence of CTC Grade 3 or 4 after 2 dose reductions

Discontinue patient from study

  1. a these criteria meet the CTCAE version 3.0 (NCI 2003) definition of febrile neutropenia