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Table 1 Correlation between histoclinical markers and Nectin-4 expression determined by IHC

From: Nectin-4 is a new histological and serological tumor associated marker for breast cancer

Characteristics   N° of patients (%) P-value
   Nectin4 negative (N=39) 68.4% Nectin4 positive (N=18) 31.6%  
Age <50 5 (14) 4 (29) NS
  >50 31 (86) 10 (71)  
Histological type Ductal 10 (26) 16 (89) <0.0001
  Lobular 29 (74) 2 (11)  
SBR grade I 9 (25) 3 (21) NS
  II 17 (47) 6 (43)  
  III 10 (28) 5 (36)  
Axillary lymph node st. Negative 19 (53) 6 (43) NS
  Positive 17 (47) 8 (57)  
EGFR Negative 31 (94) 7 (54) 0.0012
  Positive 2 (6) 6 (46)  
ERBB2 status 0-1 34 (94) 10 (71) 0.0245
  2-3 2 (6) 4 (29)  
Ki67 Negative 23 (79) 7 (50) 0.05
  Positive 6 (21) 7 (50)  
P53 status Negative 33 (97) 7 (50) <0.0001
  Positive 1 (3) 7 (50)  
P-cadherin Negative 25 (74) 4 (29) 0.0029
  Positive 9 (26) 11 (71)  
BCL2 Negative 2 (6) 6 (43) 0.0025*
  Positive 30 (94) 8 (57)  
Estrogen receptor st. Negative 0 (0) 7 (50) <0.0001*
  Positive 37 (100) 7 (50)  
GATA3 Negative 3 (9) 6 (60) 0.0004*
  Positive 31 (91) 4 (40)  
Progesterone receptor st. Negative 8 (24) 8 (57) 0.0247*
  Positive 26 (76) 6 (43)  
  1. * Negative correlation with Nectin-4 expression