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Figure 4 | BMC Cancer

Figure 4

From: Nectin-4 is a new histological and serological tumor associated marker for breast cancer

Figure 4

Detection of Nectin-4 in serum from patients with MBC. Serum Nectin-4 was detected by ELISA using a pair of anti-Nectin-4 mAbs. A: Percentage of Nectin-4 positive sera in healthy donors (n = 45), and in patients with non-metastatic breast tumors compared with CEA and CA15.3 levels (n = 53). B: Percentage of sera positive for Nectin-4, CEA and CA15.3 and combinations of markers. The association of Nectin-4 with CEA and CA15.3 increases the percentage of patients detected. White bars; patients with metachronous MBC. Grey bars; patients with synchronous MBC. Black bars; percentage including both groups. C: ROC curves were calculated to estimate the accuracy of the association of these markers in breast cancer diagnosis.

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