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Table 3 Frequency of CIMP in MSI-L/MSS tumors with or without 18q LOH after various stratifications

From: 18q loss of heterozygosity in microsatellite stable colorectal cancer is correlated with CpG island methylator phenotype-negative (CIMP-0) and inversely with CIMP-low and CIMP-high

 

18q LOH status

Total N

CIMP-0 (0/8)a

CIMP-low/high (1/8 – 8/8)a

P value

CIMP-low (1/8 – 5/8)

CIMP-high (6/8 – 8/8)

Men

(+)

104

59 (57%)

45 (43%)

0.02

41 (39%)

4 (3.8%)

 

(-)

70

28 (40%)

42 (60%)

 

39 (56%)

3 (4.3%)

Women

(+)

132

80 (61%)

52 (39%)

 

47 (36%)

5 (3.8%)

 

(-)

68

33 (49%)

35 (51%)

 

30 (44%)

5 (7.4%)

Right colon

(+)

45

19 (42%)

26 (58%)

 

23 (51%)

3 (6.7%)

 

(-)

37

12 (32%)

25 (68%)

 

21 (57%)

4 (11%)

Left colon

(+)

87

54 (62%)

33 (38%)

 

32 (36%)

1 (1.9%)

 

(-)

34

16 (47%)

18 (53%)

 

18 (53%)

0

p53(+)^

(+)

122

73 (60%)

49 (40%)

 

48 (39%)

1 (0.8%)

 

(-)

43

19 (44%)

24 (56%)

 

22 (51%)

2 (4.7%)

p53(-)^

(+)

113

66 (58%)

47 (42%)

0.03

39 (35%)

8 (7.1%)

 

(-)

90

39 (43%)

51 (57%)

 

45 (50%)

6 (6.7%)

KRAS(-) BRAF(-)

(+)

142

93 (65%)

49 (35%)

 

47 (33%)

2 (1.4%)

 

(-)

51

30 (59%)

21 (41%)

 

21 (41%)

0

KRAS(+) BRAF(-)

(+)

71

39 (55%)

32 (45%)

 

31 (44%)

1 (1.4%)

 

(-)

72

30 (42%)

42 (58%)

 

39 (54%)

3 (4.2%)

KRAS(-) BRAF(+)

(+)

17

3 (18%)

14 (82%)

 

8 (47%)

6 (35%)

 

(-)

12

0

12 (100%)

 

7 (58%)

5 (42%)

  1. The frequency of CIMP-0 is consistently higher in 18q LOH(+) tumors than in 18q LOH(-) tumors among the 9 different categories (men, women, right colon, etc.; 11 categories including MSI-L and MSS, p = 0.0005).
  2. Footnote: a Fraction of the number of methylated promoters. ^ p53 status was assessed by immunohistochemistry.
  3. CIMP, CpG island methylator phenotype; LOH, loss of heterozygosity; MSI-L, microsatellite instability-low; MSS, microsatellite stable.