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Table 3 Frequency of CIMP in MSI-L/MSS tumors with or without 18q LOH after various stratifications

From: 18q loss of heterozygosity in microsatellite stable colorectal cancer is correlated with CpG island methylator phenotype-negative (CIMP-0) and inversely with CIMP-low and CIMP-high

  18q LOH status Total N CIMP-0 (0/8)a CIMP-low/high (1/8 – 8/8)a P value CIMP-low (1/8 – 5/8) CIMP-high (6/8 – 8/8)
Men (+) 104 59 (57%) 45 (43%) 0.02 41 (39%) 4 (3.8%)
  (-) 70 28 (40%) 42 (60%)   39 (56%) 3 (4.3%)
Women (+) 132 80 (61%) 52 (39%)   47 (36%) 5 (3.8%)
  (-) 68 33 (49%) 35 (51%)   30 (44%) 5 (7.4%)
Right colon (+) 45 19 (42%) 26 (58%)   23 (51%) 3 (6.7%)
  (-) 37 12 (32%) 25 (68%)   21 (57%) 4 (11%)
Left colon (+) 87 54 (62%) 33 (38%)   32 (36%) 1 (1.9%)
  (-) 34 16 (47%) 18 (53%)   18 (53%) 0
p53(+)^ (+) 122 73 (60%) 49 (40%)   48 (39%) 1 (0.8%)
  (-) 43 19 (44%) 24 (56%)   22 (51%) 2 (4.7%)
p53(-)^ (+) 113 66 (58%) 47 (42%) 0.03 39 (35%) 8 (7.1%)
  (-) 90 39 (43%) 51 (57%)   45 (50%) 6 (6.7%)
KRAS(-) BRAF(-) (+) 142 93 (65%) 49 (35%)   47 (33%) 2 (1.4%)
  (-) 51 30 (59%) 21 (41%)   21 (41%) 0
KRAS(+) BRAF(-) (+) 71 39 (55%) 32 (45%)   31 (44%) 1 (1.4%)
  (-) 72 30 (42%) 42 (58%)   39 (54%) 3 (4.2%)
KRAS(-) BRAF(+) (+) 17 3 (18%) 14 (82%)   8 (47%) 6 (35%)
  (-) 12 0 12 (100%)   7 (58%) 5 (42%)
  1. The frequency of CIMP-0 is consistently higher in 18q LOH(+) tumors than in 18q LOH(-) tumors among the 9 different categories (men, women, right colon, etc.; 11 categories including MSI-L and MSS, p = 0.0005).
  2. Footnote: a Fraction of the number of methylated promoters. ^ p53 status was assessed by immunohistochemistry.
  3. CIMP, CpG island methylator phenotype; LOH, loss of heterozygosity; MSI-L, microsatellite instability-low; MSS, microsatellite stable.