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Table 2 Frequencies of CIMP-0 and CIMP-low/high in MSI-L/MSS colorectal cancer with or without 18q LOH

From: 18q loss of heterozygosity in microsatellite stable colorectal cancer is correlated with CpG island methylator phenotype-negative (CIMP-0) and inversely with CIMP-low and CIMP-high

  18q LOH status Total N CIMP-0 (0/8)a CIMP-low/high (1/8 – 8/8)a P value CIMP-low (1/8 – 5/8)a CIMP-high (6/8 – 8/8)a
All cases   920 431 (47%) 489 (53%)   353 (38%) 136 (15%)
MSI-L/MSS (+) 236 139 (59%) 97 (41%) 0.002 88 (37%) 9 (3.8%)
  (-) 138 61 (44%) 77 (56%)   69 (50%) 8 (5.8%)
MSI-L (+) 23 15 (65%) 8 (35%)   6 (26%) 2 (8.7%)
  (-) 5 1 (20%) 4 (80%)   3 (60%) 1 (20%)
MSS (+) 213 124 (58%) 89 (42%) 0.01 82 (38%) 7 (3.3%)
  (-) 133 60 (45%) 73 (55%)   66 (50%) 7 (5.3%)
  1. a Fraction of the number of methylated promoters.
  2. CIMP, CpG island methylator phenotype; LOH, loss of heterozygosity; MSI-L, microsatellite instability-low; MSS, microsatellite stable.