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Table 2 Frequencies of CIMP-0 and CIMP-low/high in MSI-L/MSS colorectal cancer with or without 18q LOH

From: 18q loss of heterozygosity in microsatellite stable colorectal cancer is correlated with CpG island methylator phenotype-negative (CIMP-0) and inversely with CIMP-low and CIMP-high

 

18q LOH status

Total N

CIMP-0 (0/8)a

CIMP-low/high (1/8 – 8/8)a

P value

CIMP-low (1/8 – 5/8)a

CIMP-high (6/8 – 8/8)a

All cases

 

920

431 (47%)

489 (53%)

 

353 (38%)

136 (15%)

MSI-L/MSS

(+)

236

139 (59%)

97 (41%)

0.002

88 (37%)

9 (3.8%)

 

(-)

138

61 (44%)

77 (56%)

 

69 (50%)

8 (5.8%)

MSI-L

(+)

23

15 (65%)

8 (35%)

 

6 (26%)

2 (8.7%)

 

(-)

5

1 (20%)

4 (80%)

 

3 (60%)

1 (20%)

MSS

(+)

213

124 (58%)

89 (42%)

0.01

82 (38%)

7 (3.3%)

 

(-)

133

60 (45%)

73 (55%)

 

66 (50%)

7 (5.3%)

  1. a Fraction of the number of methylated promoters.
  2. CIMP, CpG island methylator phenotype; LOH, loss of heterozygosity; MSI-L, microsatellite instability-low; MSS, microsatellite stable.