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Table 1 Frequency of methylation in each marker according to 18q LOH status in MSI-L/MSS colorectal cancers

From: 18q loss of heterozygosity in microsatellite stable colorectal cancer is correlated with CpG island methylator phenotype-negative (CIMP-0) and inversely with CIMP-low and CIMP-high

18q LOH status Total N No. of tumors with methylation in:
   CACNA1G CDKN2A (p16) CRABP1 IGF2 MLH1 NEUROG1 RUNX3 SOCS1
LOH(+) 236 23 (9.7%) 55 (23%) 44 (19%) 28 (12%) 4 (1.7%) 44 (19%) 15 (6.4%) 15 (6.4%)
LOH(-) 138 26 (19%) 38 (28%) 47 (34%) 30 (22%) 3 (2.2%) 41 (30%) 23 (17%) 14 (10%)
  1. Abbreviations: LOH, loss of heterozygosity; MSI-L, microsatellite instability-low; MSS, microsatellite stable.