Distribution of MSI-L/MSS colorectal cancers according to the number of methylated promoters. The X and Y axes indicate the number of methylated promoters and the number of tumors, respectively. Based on the KRAS and BRAF mutation rates, CIMP-high is defined as the presence of ≥ 6/8 methylated promoters. Also note that CIMP-0 tumors with 0/8 methylated promoters are more likely to have both wild-type KRAS and BRAF, compared to CIMP-low tumors with 1/8 to 5/8 methylated promoters. Abbreviations: BRAF+, BRAF-mutated KRAS wild-type; KRAS+, KRAS-mutated BRAF wild-type; K+/B+, KRAS-mutated BRAF-mutated; KRAS/BRAF WT, both wild-type KRAS and BRAF; MSI-L, microsatellite instability-low; MSS, microsatellite stable.