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Figure 1 | BMC Cancer

Figure 1

From: 18q loss of heterozygosity in microsatellite stable colorectal cancer is correlated with CpG island methylator phenotype-negative (CIMP-0) and inversely with CIMP-low and CIMP-high

Figure 1

Distribution of MSI-L/MSS colorectal cancers according to the number of methylated promoters. The X and Y axes indicate the number of methylated promoters and the number of tumors, respectively. Based on the KRAS and BRAF mutation rates, CIMP-high is defined as the presence of ≥ 6/8 methylated promoters. Also note that CIMP-0 tumors with 0/8 methylated promoters are more likely to have both wild-type KRAS and BRAF, compared to CIMP-low tumors with 1/8 to 5/8 methylated promoters. Abbreviations: BRAF+, BRAF-mutated KRAS wild-type; KRAS+, KRAS-mutated BRAF wild-type; K+/B+, KRAS-mutated BRAF-mutated; KRAS/BRAF WT, both wild-type KRAS and BRAF; MSI-L, microsatellite instability-low; MSS, microsatellite stable.

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