Table 4 Univariate analyses of clinicopathological factors and molecular markers
| Â | Â | Number | 3 yr DFS | P | 3 yr OS | P |
|---|---|---|---|---|---|---|
Tumor size | < 5 cm ≥5 cm | 121 30 | 78.6% 42.3% | 0.038 | 92.1% 91.1% | 0.952 |
Number of lymph nodes | 4–9 ≥10 | 79 72 | 89.8% 52.7% | < 0.001 | 100% 83.7% | 0.001 |
Surgery | MRM BCS | 120 31 | 70.0% 79.0% | 0.808 | 90.9% 96.3% | 0.953 |
Histology | Ductal Others | 138 13 | 71.1% 76.9% | 0.461 | 91.0% 100.0% | 0.323 |
Histologic grade | I, II III | 65 76 | 74.7% 69.5% | 0.160 | 98.4% 84.3% | 0.043 |
Endolymphatic tumor emboli | absent present | 5 116 | 55.6% 71.7% | 0.459 | 100% 91.6% | 0.490 |
Close RM | ≤2 mm > 2 mm | 5 146 | 70.8% 80.0% | 0.590 | 91.5% 100% | 0.475 |
ER | (-) (+) | 68 83 | 64.9% 77.2% | 0.013 | 83.4% 100% | 0.006 |
PR | (-) (+) | 92 59 | 68.3% 76.2% | 0.136 | 87.1% 100% | 0.121 |
p53 | ≤25% >25% | 105 46 | 75.5% 62.1% | 0.032 | 93.8% 87.8% | 0.213 |
bcl-2 | (-) (+) | 59 92 | 62.0% 77.6% | 0.002 | 83.9% 97.4% | 0.009 |
c-erbB2 | (-) to (2+) (3+) | 121 30 | 74.3% 60.6% | 0.112 | 96.3% 79.6% | 0.050 |
Ki-67 | < 5% ≥5% | 94 56 | 85.6% 61.8% | 0.146 | 91.0% 92.4% | 0.631 |