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Table 2 Risk of epithelial ovarian cancer and polymorphisms in SHBG and its 3' neighbor ATP1B2, among 264 ovarian cancer cases and 625 controls in the Polish Ovarian Cancer Study*

From: Ovarian cancer risk and common variation in the sex hormone-binding globulin gene: a population-based case-control study

Gene SNP   Cases Controls OR** 95% CI P-trend
SHBG       
rs1799941 AA 144 278 1.00   
-67G>A AG 118 287 0.79 0.59 – 1.07  
5'UTR GG 23 57 0.79 0.46 – 1.33 0.14
rs6257 TT 242 520 1.00   
IVS1-17T>C TC 41 91 0.97 0.65 – 1.44  
  CC 2 2 2.13 0.29 – 15.3 0.75
rs6259 AA 254 547 1.00   
Ex8+6G>A AG 30 72 0.89 0.57 – 1.40  
D356N GG 1 4 0.51 0.06 – 4.65 0.72
rs727428 CC 119 264 1.00   
1121 bp 3' of STP T>C CT 121 278 0.96 0.71 – 1.30  
  TT 45 81 1.25 0.81 – 1.91 0.48
rs1641544 CC 261 580 1.00   
31959 bp 3' of STP T>C CT 22 38 1.34 0.77 – 2.33 0.30
  TT 1 0    
ATP1B2       
rs1641537 *** CC 215 486 1.00   
-9115T>C CT 66 125 1.21 0.86 – 1.71  
  TT 3 8 0.90 0.23 – 3.46 0.36
rs1624085 CC 116 246 1.00   
Ex2G>C CG 120 292 0.86 0.64 – 1.18  
  GG 49 84 1.25 0.82 – 1.90 0.60
rs1641512 GG 193 401 1.00   
Ex7+414G>A GA 80 195 0.86 0.63 – 1.17  
  AA 12 27 0.94 0.46 – 1.90 0.42
  1. * Differences between the total number of cases and controls and frequencies shown in the table are due to missing genotype data.
  2. ** Adjusted for age and city.
  3. *** Highly correlated with ATP1B1 rs1641536 (18852T>C) and rs1641535 (-8703T>c), r2 > 0.98, not shown in table to avoid redundancy.