Ovarian cancer risk and common variation in the sex hormone-binding globulin gene: a population-based case-control study

Table 2 Risk of epithelial ovarian cancer and polymorphisms in SHBG and its 3' neighbor ATP1B2, among 264 ovarian cancer cases and 625 controls in the Polish Ovarian Cancer Study*

Gene SNP		Cases	Controls	OR**	95% CI	P-trend
*SHBG*
rs1799941	AA	144	278	1.00
-67G>A	AG	118	287	0.79	0.59 – 1.07
5'UTR	GG	23	57	0.79	0.46 – 1.33	0.14
rs6257	TT	242	520	1.00
IVS1-17T>C	TC	41	91	0.97	0.65 – 1.44
	CC	2	2	2.13	0.29 – 15.3	0.75
rs6259	AA	254	547	1.00
Ex8+6G>A	AG	30	72	0.89	0.57 – 1.40
D356N	GG	1	4	0.51	0.06 – 4.65	0.72
rs727428	CC	119	264	1.00
1121 bp 3' of STP T>C	CT	121	278	0.96	0.71 – 1.30
	TT	45	81	1.25	0.81 – 1.91	0.48
rs1641544	CC	261	580	1.00
31959 bp 3' of STP T>C	CT	22	38	1.34	0.77 – 2.33	0.30
	TT	1	0
*ATP1B2*
rs1641537 ***	CC	215	486	1.00
-9115T>C	CT	66	125	1.21	0.86 – 1.71
	TT	3	8	0.90	0.23 – 3.46	0.36
rs1624085	CC	116	246	1.00
Ex2G>C	CG	120	292	0.86	0.64 – 1.18
	GG	49	84	1.25	0.82 – 1.90	0.60
rs1641512	GG	193	401	1.00
Ex7+414G>A	GA	80	195	0.86	0.63 – 1.17
	AA	12	27	0.94	0.46 – 1.90	0.42

* Differences between the total number of cases and controls and frequencies shown in the table are due to missing genotype data.
** Adjusted for age and city.
*** Highly correlated with ATP1B1 rs1641536 (18852T>C) and rs1641535 (-8703T>c), r² > 0.98, not shown in table to avoid redundancy.

ISSN: 1471-2407