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Table 1 Treatment interactions between TAM-PS341 and TAM-PA in ER-positive breast cancer models.

From: Enhanced NFκB and AP-1 transcriptional activity associated with antiestrogen resistant breast cancer

A.        
   MCF7 MCF7/HER2 BT474
  TAM (500 nM) + + + + + +
  PS341 (nM) 10 25 10 25 10 25
  % of control:       
  Observed (O) 71 60 77 61 48 35
  Expected (E) 62 53 83 72 80 59
  Ratio: O/E 1.2 1.1 0.93* 0.84* 0.59* 0.59*
B.        
   MCF7 MCF7/HER2 BT474
  TAM (500 nM) + + + + + +
  Parthenolide (μM) 1 5 1 5 1 5
  % of control:       
  Observed (O) 91 44 85 44 72 8
  Expected (E) 88 42 84 52 81 13
  Ratio: O/E 1.03 1.05 1.01 0.85* 0.89* 0.62*
  1. *p < 0.01 for comparison with MCF7; primary data as originally reported (11).