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Table 1 Treatment interactions between TAM-PS341 and TAM-PA in ER-positive breast cancer models.

From: Enhanced NFκB and AP-1 transcriptional activity associated with antiestrogen resistant breast cancer

A.

       
  

MCF7

MCF7/HER2

BT474

 

TAM (500 nM)

+

+

+

+

+

+

 

PS341 (nM)

10

25

10

25

10

25

 

% of control:

      
 

Observed (O)

71

60

77

61

48

35

 

Expected (E)

62

53

83

72

80

59

 

Ratio: O/E

1.2

1.1

0.93*

0.84*

0.59*

0.59*

B.

       
  

MCF7

MCF7/HER2

BT474

 

TAM (500 nM)

+

+

+

+

+

+

 

Parthenolide (μM)

1

5

1

5

1

5

 

% of control:

      
 

Observed (O)

91

44

85

44

72

8

 

Expected (E)

88

42

84

52

81

13

 

Ratio: O/E

1.03

1.05

1.01

0.85*

0.89*

0.62*

  1. *p < 0.01 for comparison with MCF7; primary data as originally reported (11).
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BMC Cancer

ISSN: 1471-2407

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