Novel markers for differentiation of lobular and ductal invasive breast carcinomas by laser microdissection and microarray analysis

BMC Cancer

Table 1 Clinical and histopathological characteristics of breast cancer patients involved in microarray analysis

No	Diagnosis	Grade¹	AC	LN	ER³	PgR³	HER-2	Bcl-2	E-CD
1	IDC	G3	IDH	N₁	0	0	0	80%	>90%
2	IDC	G2	none	N₁	40%	0	0	80%	>90%
3	IDC	G2	none	N₀	10%	2%	0	70%	>90%
4	IDC	G3	none	N₀	90%	50%	2+ ²	100%	>90%
5	IDC	G2	DCIS	N₀	90%	1%	0	95%	>90%
6	ILC	G2	LCIS	N₀	0	0	0	30%	0
7	ILC	G1	none	N₀	80%	80%	0	100%	0
8	ILC	G1	none	N₁	50%	0	0	80%	0
9	ILC	G2	LCIS	N₁	0	0	0	<5%	0
10	ILC	G1	none	N₀	50%	70%	0	80%	0

¹Tumors were graded using the Nottingham combined histologic grading system.
²No gene amplification was detected by fluorescent in situ hybridization.
³A complete H-score was calculated by summing the products of the percentage cells stained at a given staining intensity (0–100) and the staining intensity (0–3).
AC, accompanying changes; DCIS, ductal carcinoma in situ; E-CD, E-cadherin; ER, estrogen receptor; IDC, invasive ductal carcinoma, IDH, intraductal hyperplasia; ILC, invasive lobular carcinoma; LCIS, lobular carcinoma in situ; LN, lymph node; PgR, progesterone receptor.