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Figure 5 | BMC Cancer

Figure 5

From: Silencing of the XAF1 gene by promoter hypermethylation in cancer cells and reactivation to TRAIL-sensitization by IFN-β

Figure 5

XAF1 is essential for IFN-β-mediated TRAIL-dependent apoptosis. SF539 (A) and 3 stable xaf1 shRNA clones (B-D) were treated with 0 or 500 U/mL of IFN-β for 24 hours prior to exposure to TRAIL for 14 hours. Cell viability was measured with the WST-1 assay as described in the methods and materials section. All assays were performed in triplicate and experiments were repeated at least three times.

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