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Table 2 Worst per-patient toxicity within the period of combined treatment (N = 50)

From: Vinorelbine plus 3-weekly trastuzumab in metastatic breast cancer: a single-centre phase 2 trial

Type of toxicity Patients (%)
  1 2 3 4 5
Allergy 2 (4) 2 (4) 2 (4) - -
Anemia 18 (36) 11 (22) 2 (4) - -
Leukopenia - 11 (22) 7 (14) 1 (2) -
Neutropenia - 5 (10) 13 (26) 10 (20) -
Febrile neutropenia - - 4 (8) - -
Platelets 1 (2) 2 (4) - -  
Cardiac (LVEF decline) 1 (2) 2 (4) - - -
Renal 1 (2) 1 (2) - - 1 (2)
Fatigue 12 (22) 4 (8) - - -
Fever 2 (4) 1 (2) - - -
Hair loss 1 (2) - - - -
Skin 3 (6) 4 (8) - - -
Anorexia 2 (4) - - - -
Constipation 12 (24) 3 (6) - - -
Diarrhoea 3 (6) - - - -
Nausea 5 (10) 2 (4) - - -
Stomatitis 3 (6) - - - -
Vomiting 4 (8) - - - -
Liver 1 (2) 1 (2) 1 (2) - -
Sensorial neuropathy 4 (8) - - - -
Abdominal pain 13 (26) 1 (2) 1 (2)   
RBC transfusion - - 1 (2) - -
  1. RBC = red blood cell