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Table 5 Bioclinical features of the tumours of the molecular subgroups as defined by hierarchical clustering and Chi2 analysis

From: A new molecular breast cancer subclass defined from a large scale real-time quantitative RT-PCR study

Subgroup

Number of tumours

Hormonal status

Age

Tumour size

Lymph node status

Histological grade (SBR)

Clinical outcome

 

n

% ER+

% ER-

% <50 years

% pT1

% pT2-3

% pN0

% pN1

% SBRI

% SBRII

% SBRIII

% recurrence

1

8

88

12

13

38

50

38

50

25

75

0

25

2

12

100

0

8

25

75

67

17

25

58

17

8

3/4

38

95

5

11

21

76

53

42

8

74

16

13

5

5

80

20

0

20

80

60

40

20

80

0

0

6

5

40

60

0

20

80

60

40

40

40

20

20

7

19

74

26

37

53

42

47

42

53

47

0

0

9

10

50

50

10

40

60

50

50

0

10

90

20

10

21

10

90

29

24

71

57

43

5

5

86

29

12

3

100

0

67

0

100

67

33

0

33

67

33

Overall cohort

121

70

30

18

29

68

54

40

18

49

31

15

  1. Only tumours from the Eisen's subgroups, which were correctly classified according to the Chi2 defined molecular signatures, were considered in this study (i.e. 121 out of 199). Data related to subgroup 6 did not take into account the normal breast tissues. The sum of the percentages for a given subgroup may be less than 100% as tumor size, histological grade or lymph node status were occasionally not determined.