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Table 5 Bioclinical features of the tumours of the molecular subgroups as defined by hierarchical clustering and Chi2 analysis

From: A new molecular breast cancer subclass defined from a large scale real-time quantitative RT-PCR study

Subgroup Number of tumours Hormonal status Age Tumour size Lymph node status Histological grade (SBR) Clinical outcome
  n % ER+ % ER- % <50 years % pT1 % pT2-3 % pN0 % pN1 % SBRI % SBRII % SBRIII % recurrence
1 8 88 12 13 38 50 38 50 25 75 0 25
2 12 100 0 8 25 75 67 17 25 58 17 8
3/4 38 95 5 11 21 76 53 42 8 74 16 13
5 5 80 20 0 20 80 60 40 20 80 0 0
6 5 40 60 0 20 80 60 40 40 40 20 20
7 19 74 26 37 53 42 47 42 53 47 0 0
9 10 50 50 10 40 60 50 50 0 10 90 20
10 21 10 90 29 24 71 57 43 5 5 86 29
12 3 100 0 67 0 100 67 33 0 33 67 33
Overall cohort 121 70 30 18 29 68 54 40 18 49 31 15
  1. Only tumours from the Eisen's subgroups, which were correctly classified according to the Chi2 defined molecular signatures, were considered in this study (i.e. 121 out of 199). Data related to subgroup 6 did not take into account the normal breast tissues. The sum of the percentages for a given subgroup may be less than 100% as tumor size, histological grade or lymph node status were occasionally not determined.