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Table 3 Molecular signatures specifying breast cancer subgroups as defined by hierarchical clustering and Chi2 analysis.

From: A new molecular breast cancer subclass defined from a large scale real-time quantitative RT-PCR study

SG1 SG2 SG3 SG5 SG6 SG7 SG9 SG10 SG12
ACADM ERRA BCL2 MTA3 ESR2 ABCC5 BCL2 ABCG2 AKT2
BMI1 IGF1 CCND1 SPP1 IGF1 AKT2 ERBB2 BMI1 CDKN1B
ERRG NCOA3 CDK4   KRT19 AREG GRB7 CDKN1B E4F1
MYC PTGS2 E4F1   MYBL2 EZH2 IRS1 EPHA2 EZH2
RXRA   ESR1    HDAC6 NCOA3 ERBB2 HDAC6
   GATA3    PRKAR1A PGC1A ERBB4 MAD2L1
   GSTP1     SPP1 ESR1 PR
   KRT19      GATA3 PRKAR1A
   LIV1      GSTP1 PTEN
   MAD2L1      IGF1R RXRA
   MTA3      IGFBP4  
   PGC1A      LIV1  
   SERPINB5      PR  
   TSK/E2IG4      MYBL2  
   ZNF217      MYC  
        SERPINB5  
        TFF1/pS2  
  1. These signatures included up-regulated (bold characters) or down-regulated genes as indicated. No specific signature was found concerning subgroups 4, 8 and 11, except that a high proportion of tumours from group 4 exhibited the subgroup 3-signature (see Table 4).