Table 2 Functional classes of the 47 selected genes

Steroid hormone receptors and homologs

ESR1, ESR2, PR, ERRA, ERRG, RXRA

ERα target genes

   œstrogen up-regulated

AREG, BCL2, CCND1, HDAC6, IGF1, IGFBP4, IRS1, KRT19, LIV1, MTA3, MYC PR, TFF1/pS2, TSK/E2IG4

   œstrogen down-regulated

ABCC5, GSTP1, SERPINB5/maspin

ERRα target genes

ACADM, TFF1/pS2, SPP1

ERs/ERRs regulators

NCOA3/AIB1, NCOR1, PGC1A

Genes specifying molecular subtypes

luminal A

BCL2, ESR1, GATA3, KRT19, LIV1, TFF1/pS2

luminal B/C

MYBL2

basal

GSTP1, MAD2L1, MYC, SERPINB5/maspin

ERBB2

ERBB2, GRB7

normal-like

IGF1, PGC1A

Genes involved in tamoxifen responsiveness

AKT2, CCND1, CDKN1B, EPHA2, ESR2, HDAC6, IRS1, NCOA3, NCOR1, PR, PRKAR1A, PTEN

Growth factor receptor and signaling genes

AKT2, EPHA2, ERBB2, ERBB4, IGF1R, IRS1, PTEN

Cell cycle genes

CCND1, CDK4, CDKN1B, E4F1, MAD2L1

Stem cells markers

ABCG2, BMI1, EZH2

Others

PTGS2/COX2, TACC1, ZNF217