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Table 2 HLA, APM and β2m expression in RST and HNPCC colon cancer

From: HNPCC versus sporadic microsatellite-unstable colon cancers follow different routes toward loss of HLA class I expression

   HLA APM loss β2m loss
RST
N = 81
MSS + 40 0 0
  N = 48
(59,3%)
- 8 (16,7%) 3 (37,5%)* 0
  MSI-H + 13 0 0
  N = 33
(41,7%)
- 20 (60,6%) 7 (35,0%)* 1 (5,0%)*
HNPCC
N = 75
MSI-H + 43 0 0
   - 32 (42,7%) 2 (6,3%)* 15 (46,9%)*
  1. * – The percentage of cases that lost APM or β2m expression is relative to the number of HLA negative cases of each subset
  2. † – HLA expression differs significantly between sporadic MSI-H and MSS tumors (p < 0.0001) and between HNPCC and sporadic MSS tumors (p < 0.005)
  3. ‡ – The association of HLA class I loss with that of β2m and of APM components differs significantly (p < 0.0001) between sporadic RST and HNPCC tumors.