Figure 2
Effects of liarozole fumarate (R85246) in combination with tamoxifen on N-methyl-N-nitrosourea (MNU)-induced mammary carcinoma and uterus in the rat model. Effects of liarozole alone and in combination with tamoxifen on uterine wet weight (a), uterine epithelial lining cell height (b) and PCNA index (c). Scale bars represent group mean ± SEM. Treatment groups: OVX controls, 17β-estradiol 10 μg/kg (E2), liarozole 20 mg/kg (L20), liarozole 80 mg/kg (L80), tamoxifen 1 mg/kg (T), tamoxifen 1 mg/kg + liarozole 20 mg/kg (T+L20), tamoxifen 1 mg/kg + liarozole 80 mg/kg (T+L80). *P < 0.05 versus tamoxifen 1 mg/kg (T).