Fenretinide transactivates RXRα/RARβ-mediated pathway in Huh-7, CV-1 cells, but not in HepG2 cells. Huh-7 (A), CV-1 (B), and HepG2 (C)cells were transfected with a luciferase reporter harboring RARE (DR-5) and expression plasmids for RXRα and RARβ. Firefly luciferase activity was normalized by co-transfected Renilla luciferase activity. The histograms depict the relative fold of normalized luciferase reporter activity between fenretinide treatment and DMSO treatment. Data from triplicates were presented as mean ± S.E.M.