HSP27 expression versus tumor parameters. Box-and-whisker plots of HSP27 expression versus percentage of pHH3-positive cells (A), and of HSP27 versus tumor greatest dimension (B). The open squares represent those outlier patients outside the 95% confidence interval. The black solid circles represent the mean values, while the line inside the box represents the median. Bar-chart plots of HSP27 expression versus frequency of vascular (C) and capsular (D) invasion.