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Table 3 Area fraction of vacuoles, number of apoptotic cells, mean vascular density, vascular diameter and ratio central/peripheral vessel density and vessel diameter in controls and in tumors treated with hyperoxia. Values are given as means ± SD.

From: Hyperoxia retards growth and induces apoptosis and loss of glands and blood vessels in DMBA-induced rat mammary tumors

 

Control 1 bar, 21% O2

pO2= 0.21

Test 1 bar, 100% O2

pO2= 1.0

Test 1.5 bar, 100% O2

pO2= 1.5

Area fraction vacuoles "empty spaces"

0.01 ± 0.04

0.11 ± 0.05 ***

0.21 ± 0.02 ***

Apoptotic cells (% of total cells)

61% ± 6.4

85% ± 7.3 ***

88% ± 5.0 ***

Mean vascular density (number of vessels/mm2)

   

   Centrally

98 ± 18.6

50.1 ± 17.4***

69.8 ± 18.5*

   Periphery

79.5 ± 19.2

38.5 ± 19.3***

51.8 ± 26.8*

Vascular diameter (μm)

   

   Centrally

19.1 ± 4.9

23.1 ± 9.1 **

23.2 ± 10.1**

   Periphery

10.9 ± 3.9††

12.5 ± 4.7 *††

23.9 ± 10.0 ***

Ratio central/peripheral vessel density

1.2 ± 0.7

1.6 ± 1.3

1.5 ± 1.1*

Ratio central/peripheral vessel diameter

1.9 ± 0.8

2.0 ± 1.2

1.1 ± 0.6***

  1. *P < 0.05, **P < 0.01, ***P < 0.001 vs control (1 bar, air)
  2. ††P < 0.01 vs centrally