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Table 3 Area fraction of vacuoles, number of apoptotic cells, mean vascular density, vascular diameter and ratio central/peripheral vessel density and vessel diameter in controls and in tumors treated with hyperoxia. Values are given as means ± SD.

From: Hyperoxia retards growth and induces apoptosis and loss of glands and blood vessels in DMBA-induced rat mammary tumors

  Control 1 bar, 21% O2
pO2= 0.21
Test 1 bar, 100% O2
pO2= 1.0
Test 1.5 bar, 100% O2
pO2= 1.5
Area fraction vacuoles "empty spaces" 0.01 ± 0.04 0.11 ± 0.05 *** 0.21 ± 0.02 ***
Apoptotic cells (% of total cells) 61% ± 6.4 85% ± 7.3 *** 88% ± 5.0 ***
Mean vascular density (number of vessels/mm2)    
   Centrally 98 ± 18.6 50.1 ± 17.4*** 69.8 ± 18.5*
   Periphery 79.5 ± 19.2 38.5 ± 19.3*** 51.8 ± 26.8*
Vascular diameter (μm)    
   Centrally 19.1 ± 4.9 23.1 ± 9.1 ** 23.2 ± 10.1**
   Periphery 10.9 ± 3.9†† 12.5 ± 4.7 *†† 23.9 ± 10.0 ***
Ratio central/peripheral vessel density 1.2 ± 0.7 1.6 ± 1.3 1.5 ± 1.1*
Ratio central/peripheral vessel diameter 1.9 ± 0.8 2.0 ± 1.2 1.1 ± 0.6***
  1. *P < 0.05, **P < 0.01, ***P < 0.001 vs control (1 bar, air)
  2. ††P < 0.01 vs centrally