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Table 4 Ratios of total meat to total fruit, berry and vegetable intake and the risk of colorectal carcinomas and adenomas by GST and EPHX1 genotypes

From: Meat, vegetables and genetic polymorphisms and the risk of colorectal carcinomas and adenomas

  

OR (95% CI)a (Ncases/Ncontrols)

Case group

Ratio of total meat to total fruit, berry and vegetable intakeb

GSTM1

GSTP1Ile105Val

EPHX1Tyr113His

EPHX1His139Arg

  

Present

Null

Ile/Ile

Ile/Val+Val/Val

Tyr/Tyr

Tyr/His+His/His

His/His

His/Arg+Arg/Arg

Carcinomas

Q 1

1 (ref) (11/39)

1 (ref) (11/36)

1 (ref) (7/32)

1 (ref) (15/43)

1 (ref) (10/33)

1 (ref) (10/42)

1 (ref) (9/51)

1 (ref) (11/24)

 

Q 2

0.84 (0.20–3.47) (11/33)

2.99 (0.85–10.5) (18/40)

2.01 (0.53–7.67) (16/27)

1.52 (0.43–5.35) (13/46)

3.28 (0.63–17.0) (17/29)

1.65 (0.51–5.41) (12/44)

4.67 (1.21–18.0) (17/48)

0.69 (0.17–2.89) (12/25)

 

Q 3

1.05 (0.31–3.57) (19/43)

2.39 (0.63–9.02) (18/32)

1.85 (0.48–7.18) (15/31)

1.22 (0.36–4.13) (22/44)

2.59 (0.47–14.3) (18/36)

1.34 (0.40–4.42) (17/39)

2.78 (0.71–11.0) (20/45)

0.63 (0.16–2.55) (14/30)

 

Q 4

0.49 (0.10–2.41) (12/33)

0.78 (0.19–3.23) (8/42)

1.61 (0.41–6.40) (13/28)

0.11 (0.01–0.88) (7/47)

0.70 (0.11–4.59) (7/33)

0.63 (0.16–2.52) (11/42)

0.90 (0.20–4.13) (10/46)

0.34 (0.07–1.72) (8/29)

  

Ptrend = 0.55

Ptrend = 0.51

Ptrend = 0.58

Ptrend = 0.10

Ptrend = 0.56

Ptrend = 0.51

Ptrend = 0.74

Ptrend = 0.21

High-risk Adenomas

Q 1

1 (ref) (11/39)

1 (ref) (11/36)

1 (ref) (9/32)

1 (ref) (13/43)

1 (ref) (5/33)

1 (ref) (17/42)

1 (ref) (15/51)

1 (ref) (7/24)

 

Q 2

3.52 (1.26–9.85) (32/33)

2.05 (0.80–5.26) (23/40)

2.54 (0.85–7.54) (20/27)

2.67 (1.09–6.51) (35/46)

8.98 (2.54–31.8) (33/29)

1.26 (0.52–3.05) (22/44)

2.55 (1.05–6.24) (29/48)

2.68 (0.88–8.19) (26/25)

 

Q 3

1.49 (0.53–4.21) (22/43)

1.57 (0.59–4.20) (23/32)

1.32 (0.42–4.16) (12/31)

1.42 (0.57–3.56) (33/44)

3.38 (0.90–12.75) (16/36)

1.08(0.45–2.63) (29/39)

2.00 (0.81–4.94) (31/45)

0.93 (0.28–3.10) (14/30)

 

Q 4

1.83 (0.59–5.63) (19/33)

1.91 (0.74–4.92) (32/42)

1.89 (0.60–5.95) (16/28)

1.68 (0.67–4.19) (35/47)

3.65 (1.00–13.3) (21/33)

1.44 (0.59–3.52) (30/42)

1.94 (0.77–4.88) (31/46)

1.65 (0.52–5.26) (20/29)

  

Ptrend = 0.81

Ptrend = 0.34

Ptrend = 0.59

Ptrend = 0.74

Ptrend = 0.67

Ptrend = 0.51

Ptrend = 0.33

Ptrend = 0.94

Low-risk adenomas

Q 1

1 (ref) (36/39)

1 (ref) (54/36)

1 (ref) (44/32)

1 (ref) (46/43)

1 (ref) (38/33)

1 (ref) (52/42)

1 (ref) (57/51)

1 (ref) (33/24)

 

Q 2

2.62 (1.28–5.35) (65/33)

1.32 (0.70–2.48) (77/40)

1.38 (0.67–2.83) (52/27)

2.02 (1.08–3.77) (90/46)

2.65 (1.28–5.46) (83/29)

1.15 (0.61–2.14) (59/44)

1.67 (0.94–2.98) (82/48)

1.86 (0.83–4.15) (60/25)

 

Q 3

1.89 (0.96–3.74) (81/43)

1.63 (0.85–3.12) (94/32)

1.42 (0.71–2.85) (70/31)

1.86 (1.00–3.47) (105/44)

2.07 (1.02–4.20) (93/36)

1.36 (0.73–2.54) (82/39)

1.64 (0.91–2.93) (97/45)

1.70 (0.78–3.71) (78/30)

 

Q 4

1.89 (0.90–3.98) (80/33)

1.06 (0.55–2.04) (88/42)

1.25 (0.60–2.65) (74/28)

1.43 (0.75–2.73) (94/47)

1.57 (0.74–3.35) (90/33)

1.23 (0.65–2.33) (79/42)

1.52 (0.83–2.79) (111/46)

1.13 (0.50–2.56) (58/29)

  

Ptrend = 0.25

Ptrend = 0.80

Ptrend = 0.55

Ptrend = 0.48

Ptrend = 0.49

Ptrend = 0.46

Ptrend = 0.22

Ptrend = 0.98

  1. a OR adjusted for age, gender, smoking dose and alcohol consumption.
  2. b Quartiles of ratio of total meat to total fruit, berry and vegetable intake, per day: ≤ 0.19, >0.19 and ≤ 0.38, > 0.38 and ≤ 0.71, > 0.71.
  3. ref: The combination served as a reference.