Table 3 Association between GST and EPHX1 genotypes and colorectal carcinomas and adenomas
From: Meat, vegetables and genetic polymorphisms and the risk of colorectal carcinomas and adenomas
Controls | Carcinomas | OR (95% CI)a | High-risk adenomas | OR (95% CI)a | Low-risk adenomas | OR (95% CI)a | |
|---|---|---|---|---|---|---|---|
Genotypes b | |||||||
GSTM1 | |||||||
Present | 148 | 53 | 1 (ref) | 84 | 1 (ref) | 262 | 1 (ref) |
Null | 151 | 55 | 1.22 (0.65–2.30) | 89 | 0.98 (0.63–1.52) | 313 | 1.09 (0.80–1.49) |
GSTT1 | |||||||
Present | 262 | 93 | 1 (ref) | 143 | 1 (ref) | 488 | 1 (ref) |
Null | 37 | 15 | 1.37 (0.57–3.31) | 30 | 1.36 (0.72–2.55) | 87 | 0.99 (0.63–1.58) |
GSTP1 Ile 105 Val | |||||||
Ile/Ile | 119 | 51 | 1 (ref) | 57 | 1 (ref) | 240 | 1 (ref) |
Ile/Val | 140 | 50 | 0.82 (0.43–1.59) | 90 | 1.27 (0.78–2.06) | 272 | 1.00 (0.71–1.39) |
Val/Val | 40 | 7 | 0.38 (0.12–1.23) | 26 | 1.29 (0.65–2.59) | 63 | 0.79 (0.48–1.32) |
Ile/Val + Val/Val | 180 | 57 | 0.71 (0.38–1.32) | 116 | 1.27 (0.80–2.02) | 335 | 0.95 (0.69–1.31) |
Ptrend = 0.13 | Ptrend = 0.35 | Ptrend = 0.49 | |||||
EPHX1 Tyr 113 His | |||||||
Tyr/Tyr | 132 | 52 | 1 (ref) | 75 | 1 (ref) | 304 | 1 (ref) |
Tyr/His | 134 | 41 | 0.74 (0.37–1.47) | 81 | 0.90 (0.57–1.44) | 229 | 0.69 (0.50–0.97) |
His/His | 33 | 9 | 1.04 (0.33–3.21) | 17 | 0.87 (0.40–1.88) | 43 | 0.56 (0.32–0.99) |
Tyr/His + His/His | 167 | 50 | 0.78 (0.41–1.51) | 98 | 0.90 (0.57–1.40) | 272 | 0.67 (0.49–0.92) |
Ptrend = 0.68 | Ptrend = 0.63 | Ptrend = 0.01 | |||||
EPHX1 His 139 Arg | |||||||
His/His | 190 | 56 | 1 (ref) | 106 | 1 (ref) | 347 | 1 (ref) |
His/Arg | 90 | 27 | 1.24 (0.60–2.57) | 59 | 1.37 (0.85–2.21) | 207 | 1.24 (0.88–1.74) |
Arg/Arg | 19 | 18 | 2.70 (0.96–7.58) | 8 | 0.62 (0.23–1.70) | 22 | 0.51 (0.25–1.06) |
His/Arg + Arg/Arg | 109 | 45 | 1.52 (0.79–2.93) | 67 | 1.22 (0.77–1.91) | 229 | 1.11 (0.80–1.53) |
Ptrend = 0.09 | Ptrend = 0.82 | Ptrend = 0.83 |