Biological characterization of two xenografts derived from human CUPs (carcinomas of unknown primary)

BMC Cancer

Table 2 Immunohistological phenotyping of xenografted CUPs and corresponding clinical specimens

	Capi1 clinical specimen	Capi1 xenograft	Capi3 clinical specimen	Capi3 xenograft
EMA	90% ++	100% +++	100% +++	90% +++
CEA	100% +++	100% +++	100% +++	100% +++
CK7	100% +++	100% ++	100% ++	100% ++
CK20	negative	negative	30% +	negative
TTF1	negative	negative	negative	10% ++
EGF-R	90% ++	negative	negative	negative
c-kit	negative	negative	70% +	50% +++

Values correspond to the percentage of positive cells and the staining intensity.

ISSN: 1471-2407