Table 2 Biologic pathways and clusters enriched by the outlier transcripts
Gene Ontology Term | Annotated transcripts on array | Annotated transcripts in outliers (all 6 cases) | aP-values (6 cases) | Annotated transcripts in outliers (3 responder cases) | bP-values (3 responder cases) | cAnnotated transcripts in outliers (3 non-responder cases) |
|---|---|---|---|---|---|---|
All pathways and clusters | 15 047 | 167 | -- | 188 | -- | 94 |
Lipid metabolism | 754 | 21 | NS | 30 | 2.76 × 10-4 | 4 |
Cellular lipid metabolism | 602 | 18 | NS | 29 | 9.65 × 10-6 | 3 |
Lipid biosynthesis | 255 | 17 | 3.93 × 10-5 | 28 | 1.33 × 10-13 | 3 |
Alcohol metabolism | 324 | 11 | NS | 23 | 3.44 × 10-7 | 0 |
Steroid metabolism | 198 | 12 | 1.17 × 10-2 | 24 | 2.36 × 10-12 | 1 |
Steroid biosynthesis | 90 | 12 | 4.47 × 10-6 | 23 | 5.58 × 10-19 | 1 |
Sterol metabolism | 93 | 11 | 7.12 × 10-5 | 21 | 5.46 × 10-16 | 0 |
Sterol biosynthesis | 44 | 11 | 3.07 × 10-8 | 20 | 9.91 × 10-22 | 0 |
Cholesterol metabolism | 85 | 11 | 3.01 × 10-5 | 19 | 3.58 × 10-14 | 0 |
Cholesterol biosynthesis* | 36 | 11 | 4.13 × 10-9 | 18 | 3.50 × 10-20 | 0 |
Isoprenoid metabolism | 18 | 5 | 2.39 × 10-2 | 7 | 3.73 × 10-5 | 0 |
Isoprenoid biosynthesis | 16 | 5 | 1.45 × 10-2 | 7 | 1.65 × 10-5 | 0 |
Mitotic cell cycle | 319 | 4 | NS | 15 | 4.61 × 10-2 | 0 |
Nuclear division | 268 | 2 | NS | 14 | 2.97 × 10-2 | 0 |
M phase of mitotic cell cycle | 213 | 2 | NS | 14 | 2.70 × 10-3 | 0 |
Mitosis | 209 | 2 | NS | 14 | 2.20 × 10-3 | 0 |
Phosphate transport | 106 | 8 | NS | 10 | 5.30 × 10-3 | 0 |