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Table 2 Biologic pathways and clusters enriched by the outlier transcripts

From: Coordinate up-regulation of TMEM97 and cholesterol biosynthesis genes in normal ovarian surface epithelial cells treated with progesterone: implications for pathogenesis of ovarian cancer

Gene Ontology Term Annotated transcripts on array Annotated transcripts in outliers (all 6 cases) aP-values (6 cases) Annotated transcripts in outliers (3 responder cases) bP-values (3 responder cases) cAnnotated transcripts in outliers (3 non-responder cases)
All pathways and clusters 15 047 167 -- 188 -- 94
Lipid metabolism 754 21 NS 30 2.76 × 10-4 4
Cellular lipid metabolism 602 18 NS 29 9.65 × 10-6 3
Lipid biosynthesis 255 17 3.93 × 10-5 28 1.33 × 10-13 3
Alcohol metabolism 324 11 NS 23 3.44 × 10-7 0
Steroid metabolism 198 12 1.17 × 10-2 24 2.36 × 10-12 1
Steroid biosynthesis 90 12 4.47 × 10-6 23 5.58 × 10-19 1
Sterol metabolism 93 11 7.12 × 10-5 21 5.46 × 10-16 0
Sterol biosynthesis 44 11 3.07 × 10-8 20 9.91 × 10-22 0
Cholesterol metabolism 85 11 3.01 × 10-5 19 3.58 × 10-14 0
Cholesterol biosynthesis* 36 11 4.13 × 10-9 18 3.50 × 10-20 0
Isoprenoid metabolism 18 5 2.39 × 10-2 7 3.73 × 10-5 0
Isoprenoid biosynthesis 16 5 1.45 × 10-2 7 1.65 × 10-5 0
Mitotic cell cycle 319 4 NS 15 4.61 × 10-2 0
Nuclear division 268 2 NS 14 2.97 × 10-2 0
M phase of mitotic cell cycle 213 2 NS 14 2.70 × 10-3 0
Mitosis 209 2 NS 14 2.20 × 10-3 0
Phosphate transport 106 8 NS 10 5.30 × 10-3 0
  1. a Fisher's exact test, corrected for multiple pathway testing (n = 551).
  2. b Fisher's exact test, corrected for multiple pathway testing (n = 542).
  3. c No significant enrichment for any of the 449 pathways.
  4. NS: Not significant
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