Skip to main content

Advertisement

Figure 1 | BMC Cancer

Figure 1

From: Inhibition of PC cell-derived growth factor (PCDGF)/granulin-epithelin precursor (GEP) decreased cell proliferation and invasion through downregulation of cyclin D and CDK 4 and inactivation of MMP-2

Figure 1

PCDGF expression in three ovarian cancer cell lines and its correlation with their malignant phenotype. A, PCDGF mRNA expression levels in SW626, A2780 and SKOV3 cell lines were determined by RT-PCR. The figure shows a representative result of three independent experiments. B, PCDGF protein expression levels in SW626, A2780 and SKOV3 cell lines were determined by western blot. Also the figure shows a representative result of three independent experiments. C, cell proliferation capability of SW626, A2780 and SKOV3 cells determined by MTT assay. Intensity on 540 nm reflects the cell proliferation capability. Values represent the mean ± SE from three independent experiments. D, cell invasion capability of SW626, A2780 and SKOV3 cells detected by transwell chambers. The ratio of the number of cells migrating through matrigel to the number of cells migrating without matrigel was defined as invasion index. Values represent the mean ± SE from three independent experiments. E, the correlation analysis of PCDGF mRNA expression level and cell proliferation capability using Bivariate Correlations in SPSS12.0. F, the correlation analysis of PCDGF mRNA expression level and cell invasion capability using Bivariate Correlations in SPSS12.0.

Back to article page