Presence of LYVE-1-positive macrophages during bladder cancer progression. Representative photomicrographs indicating LYVE-1-positive cells resembling macrophages (red arrows) in the urinary bladders obtained from SV40-lacZ mice. A = LYVE-1 and Giemsa stain. B and C = LYVE-1 and H&E stained cross-sections. D, E, and F = MAC 387 immunohistochemistry (blue arrows) performed in serial sections of the same bladders represented in A, B, and C. Mast cells (black arrows) present in the cross-sections were positive for Giemsa stain, but negative for LYVE-1 (D and E).