Figure 18

Digital subtraction of the images between pre- and 80 minutes post-contrast. Images were acquired in two "phases" corresponding to the biphasic kinetics of the BSA-Gd-DTPA [15]. The first or "early phase" comprised of images obtained just before i.v. administration of 200 μL Gd-Cy5.5 (dose of 500 mg/kg). Starting at 3 minutes post-injection, images were acquired every 7 minutes, up to 2 hours post-contrast. The second block of MRI data was acquired up to 80 minutes after the first series of images. Images represents accumulation of Gd-Cy5.5 represented in three contiguous slices from the same bladder (positions -0.2 = A, -0.8 = B, and +0.8 = C). The red and yellow regions are active lymphatic vessels and consist of drainage events within the bladder interstitium.