Figure 5From: Deficiency of G1 regulators P53, P21Cip1and/or pRb decreases hepatocyte sensitivity to TGFβ cell cycle arrest Deficiency in p53 but not p21 Cip1 further decreases E2F activity in Rb -deficient hepatocytes. The values are the percentage decrease in E2F activity in TGFβ-treated hepatocytes of different genotypes compared with untreated cells. The E2F activity was quantified using a reporter assay as described in figure 2.Back to article page