Figure 2From: Deficiency of G1 regulators P53, P21Cip1and/or pRb decreases hepatocyte sensitivity to TGFβ cell cycle arrest TGFβ affects c-MYC and E2F transcriptional activity. The graph represents the transcriptional activities of c-MYC and E2F quantified using a reporter assay. Control and Rb-/- hepatocytes were in culture for 78 hours, treated or not with TGFβ for 30 hours at the time of the assay. The bars represent the average +/- SEM of duplicate transfections.Back to article page