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Table 3 Association between UGT1A7 and HCC

From: UDP-glucuronosyltransferase UGT1A7 genetic polymorphisms in hepatocellular carcinoma: a differential impact according to seropositivity of HBV or HCV markers?

   Controls Cirrhosis HCC HCC vs Controls HCC vs Cirrhosis
   N % N % N % OR1 95% CI OR2 95% CI
All            
  *1/*1 12 9.5% 11 8.2% 28 17.0% 1.0 Ref 1.0 Ref
  *1/*2 27 20.6% 23 17.2% 31 18.8% 0.5 0.2–1.3 0.8 0.3–2.5
  *1/*3 36 27.5% 36 26.9% 51 30.9% 0.8 0.3–2.0 0.8 0.3–2.3
  *2/*2 9 6.9% 10 7.5% 12 7.3% 0.6 0.2–2.3 0.8 0.2–3.3
  *2/*3 28 21.4% 31 23.1% 19 11.5% 0.4 0.1–1.2 0.3 0.1–1.2
  *3/*3 19 14.5% 22 16.4% 23 13.9% 0.7 0.2–2.1 0.4 0.1–1.2
  determined 131   133   164      
  H 48 33.8% 44 32.8% 71 43.0% 1.0 Ref 1.0 Ref
  HL 64 45.1% 67 50.0% 70 42.4% 1.0 0.5–1.8 0.7 0.4–1.4
  L 19 13.4% 22 16.4% 23 13.9% 1.2 0.5–2.6 0.4 0.2–1.0
   131   133   164      
Heavy drinkers virus(-)            
  *1/*1    7 6.5% 18 17.5% 1 Ref 1 Ref
  *1/*2    17 15.9% 23 22.3% 0.7 0.2–2.3 0.7 0.2–3.0
  *1/*3    29 27.1% 31 30.1% 1.1 0.4–3.2 0.5 0.1–2.0
  *2/*2    10 9.3% 9 8.8% 1.1 0.3–4.4 0.5 0.1–2.4
  *2/*3    27 25.2% 12 11.6% 0.4 0.1–1.5 0.2 0.04–0.7
  *3/*3    17 15.9% 10 9.7% 0.5 0.2–1.9 0.1 0.02–0.6
  determined    107   103      
  H    34 31.8% 50 48.5% 1.0 Ref 1.0 Ref
  HL    56 52.3% 43 41.7% 0.6 0.3–1.1 0.5 0.2–1.1
  L    17 15.9% 10 9.7% 0.5 0.2–1.2 0.2 0.04–0.6
     107   103      
Virus(+)            
  *1/*1    3 15.0% 6 15.0% 1.0 Ref 1.0 Ref
  *1/*2    4 20.0% 6 15.0% 0.6 0.1–3.9 1.3 0.1–19.7
  *1/*3    6 30.0% 11 27.5% 1.3 0.2–7.0 1.8 0.1–19.2
  *2/*2    0 0.0% 3 7.5% 0.9 0.1–8.0 -  
  *2/*3    3 15.0% 4 10.0% 0.9 0.1–5.8 6.4 0.3–140
  *3/*3    4 20.0% 10 25.0% 2.3 0.4–13.3 3.4 0.3–45
  determined    20   40      
  H    7 35.0% 15 37.5% 1.0 Ref 1.0 Ref
  HL    9 45.0% 15 37.5% 1.5 0.6–4.1 1.6 0.2–8.3
  L    4 20.0% 10 25.0% 3.1 1.0–9.6 2.2 0.3–15.3
     20   40      
  1. 1: adjusted for age, hospital, drinks/day, social class.; 2: adjusted for age, hospital, drinks/day, social class, time since cirrhosis diagnosis