UDP-glucuronosyltransferase UGT1A7 genetic polymorphisms in hepatocellular carcinoma: a differential impact according to seropositivity of HBV or HCV markers?

Table 3 Association between UGT1A7 and HCC

		Controls		Cirrhosis		HCC		HCC vs Controls		HCC vs Cirrhosis
		N	%	N	%	N	%	OR¹	95% CI	OR²	95% CI
All
	1/1	12	9.5%	11	8.2%	28	17.0%	1.0	Ref	1.0	Ref
	1/2	27	20.6%	23	17.2%	31	18.8%	0.5	0.2–1.3	0.8	0.3–2.5
	1/3	36	27.5%	36	26.9%	51	30.9%	0.8	0.3–2.0	0.8	0.3–2.3
	2/2	9	6.9%	10	7.5%	12	7.3%	0.6	0.2–2.3	0.8	0.2–3.3
	2/3	28	21.4%	31	23.1%	19	11.5%	0.4	0.1–1.2	0.3	0.1–1.2
	3/3	19	14.5%	22	16.4%	23	13.9%	0.7	0.2–2.1	0.4	0.1–1.2
	determined	131		133		164
	H	48	33.8%	44	32.8%	71	43.0%	1.0	Ref	1.0	Ref
	HL	64	45.1%	67	50.0%	70	42.4%	1.0	0.5–1.8	0.7	0.4–1.4
	L	19	13.4%	22	16.4%	23	13.9%	1.2	0.5–2.6	0.4	0.2–1.0
		131		133		164
Heavy drinkers virus(-)
	1/1			7	6.5%	18	17.5%	1	Ref	1	Ref
	1/2			17	15.9%	23	22.3%	0.7	0.2–2.3	0.7	0.2–3.0
	1/3			29	27.1%	31	30.1%	1.1	0.4–3.2	0.5	0.1–2.0
	2/2			10	9.3%	9	8.8%	1.1	0.3–4.4	0.5	0.1–2.4
	2/3			27	25.2%	12	11.6%	0.4	0.1–1.5	0.2	0.04–0.7
	3/3			17	15.9%	10	9.7%	0.5	0.2–1.9	0.1	0.02–0.6
	determined			107		103
	H			34	31.8%	50	48.5%	1.0	Ref	1.0	Ref
	HL			56	52.3%	43	41.7%	0.6	0.3–1.1	0.5	0.2–1.1
	L			17	15.9%	10	9.7%	0.5	0.2–1.2	0.2	0.04–0.6
				107		103
Virus(+)
	1/1			3	15.0%	6	15.0%	1.0	Ref	1.0	Ref
	1/2			4	20.0%	6	15.0%	0.6	0.1–3.9	1.3	0.1–19.7
	1/3			6	30.0%	11	27.5%	1.3	0.2–7.0	1.8	0.1–19.2
	2/2			0	0.0%	3	7.5%	0.9	0.1–8.0	-
	2/3			3	15.0%	4	10.0%	0.9	0.1–5.8	6.4	0.3–140
	3/3			4	20.0%	10	25.0%	2.3	0.4–13.3	3.4	0.3–45
	determined			20		40
	H			7	35.0%	15	37.5%	1.0	Ref	1.0	Ref
	HL			9	45.0%	15	37.5%	1.5	0.6–4.1	1.6	0.2–8.3
	L			4	20.0%	10	25.0%	3.1	1.0–9.6	2.2	0.3–15.3
				20		40

1: adjusted for age, hospital, drinks/day, social class.; 2: adjusted for age, hospital, drinks/day, social class, time since cirrhosis diagnosis

ISSN: 1471-2407