UDP-glucuronosyltransferase UGT1A7 genetic polymorphisms in hepatocellular carcinoma: a differential impact according to seropositivity of HBV or HCV markers?

Table 2 Classic risk factors of HCC: Alcohol consumption and HBV/HBC

	Controls (N = 142)		Cirrhosis (N = 134)		HCC (N = 165)		HCC vs Controls		HCC vs Cirrhosis
	N	%	N	%	N	%	OR^a	95%CI	OR^b	95%CI
Drinks/day ^c
0–3	58	44,3%	17	14,0%	23	17,2%	1.0	Ref	1.0	Ref
3–7	38	29,0%	23	19,0%	26	19,4%	1.8	0.9–3.7	1.4	0.5–4.1
7–11	21	16,0%	25	20,7%	40	29,9%	4.9	2.4–10.2	2.7	0.9–7.5
≥ 11	14	10,7%	56	46,3%	45	33,6%	9.5	4.2–21.1	1.5	0.6–4.0
	131^c	100,0%	121^c	100,0%	134^c	100,0%
m ± sd	5.2^d ± 5.2		11.2^d ± 8.1		9.7^d ± 9.4		3.7^f	2.1–6.4	1.07^f	0.97–1.5
m ± sd	3.3^e ± 3.4		6.7^e ± 8.3		5.1^e ± 7.1
Cirrhosis characteristic
Heavy drinkers-virus(-)			106	84,1%	102	71,8%			1.0	Ref
Virus(+)			20	15,9%	40	28,2%			3.1	1.5–6.3

a: adjusted for age and hospital b: adjusted for age, hospital, time since cirrhosis diagnosis, origin of the cirrhosis (viral(+) or not), and social class c: alcohol variable missing for 50 subjects because the food frequency questionnaire was not available at the beginning of the study d: Lifetime mean consumption e: Consumption at the time of the interview. f: OR per unit of 10 drinks/day

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