Survival | OER' (HYP/AIR) | OER' (HYPCHT/AIRCHT) |
|---|
10% | 1.49 | 1.06 |
37% | 1.86 | 1.22 |
50% | 2.02 | 1.27 |
- Modified oxygen enhancement ratio (OER') derived from clonogenic survival curves after irradiation at oxygen concentrations of 20% (AIR) or 0.1% (Hypoxia = HYP) following treatment with 150 nM chetomin (CHT) where indicated. The modified oxygen enhancement ratio (OER') was calculated as the ratio of the dosis (D) to achieve the same survival as at ambient oxygen tensions: OER' = Dhypoxia/Dnormoxia. OER was obtained at cell survival of 50%, 37% and 10%.
