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Figure 4 | BMC Cancer

Figure 4

From: Simultaneous Aurora-A/STK15 overexpression and centrosome amplification induce chromosomal instability in tumour cells with a MIN phenotype

Figure 4

Alterations of the mitotic spindle and of ploidy following Aurora-A/STK15 overexpression in HCT-wt and HCT-p53KO cells. A) Presence of multipolar spindles in HCT cells overexpressing Aurora-A/STK15 detected by β-tubulin (green) nuclei are stained with DAPI (blue): graphs summarize the percentages of normal and aberrant spindles in HCT-STK15 and HCT-p53KO-STK15 cells. B) Examples of Giemsa stained aneuploid metaphases both hypodiploid and hyperdiploid; histogram on the right shows percentages of both aneuploid and euploid metaphases in cells overexpressing Aurora-A/STK15.

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BMC Cancer

ISSN: 1471-2407

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