Figure 6From: High-level inducible Smad4-reexpression in the cervical cancer cell line C4-II is associated with a gene expression profile that predicts a preferential role of Smad4 in extracellular matrix composition Analysis of secreted TGF-β target genes in Smad4-reexpressing pancreatic carcinoma cells. Stable reexpression of Smad4 was established in BxPC3 and Capan1 human pancreatic carcinoma cells through retroviral transduction. Shown are endogenous expression levels of BigH3, fibronectin and PAI-1 in response to TGF-β treatment of, a representative Smad4-deficient control clone and a Smad4-reexpressing clone from both cell lines.Back to article page