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Figure 3 | BMC Cancer

Figure 3

From: High-level inducible Smad4-reexpression in the cervical cancer cell line C4-II is associated with a gene expression profile that predicts a preferential role of Smad4 in extracellular matrix composition

Figure 3

Restoration of TGF-β responses in Smad4-reexpressing C4-II clones. a) Phosphorylation of R-Smad2/3 in response to TGF-β was assessed through Western blotting with a phospho-Smad2/3-specific antibody. b) TGF-β response in transient transfections with the p6SBE-luc promoter; the induction factor in Smad4-reexpressing clones is 5–8. c) TGF-β response in transient transfections with the p3TP-luc promoter; induction in Smad4-negative cells is approximately 1.5 and rises to 3–4 in Smad4-reexpressing clones.

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BMC Cancer

ISSN: 1471-2407

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