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Figure 7 | BMC Cancer

Figure 7

From: PYRROLO[1,2-b][1,2,5]BENZOTHIADIAZEPINES (PBTDs) induce apoptosis in K562 cells

Figure 7

A.-Most frequent nuclear apoptotic changes include: classical nuclear body formation with clumped chromatin and nuclear fragmentation. (× 9800); the bar represents 1 μm. (K562 treated with PBTD-3). B.-An other less frequent nuclear change is displayed in this picture: chromatin clumping and membrane complex fragmentation, likely due to the degradation of laminin fibers of nuclear dense lamina by caspase-3. Note the close association between nuclear membranes (paired cysternae) and clumped chromatin. (× 2000); the bar represents 3 μm.(K562 treated with PBTD-3). C.-A detail of the insert is shown. (× 9800); the bar represents 0,5 μm.

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