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Table 4 Age and gender adjusted Odds Ratios (95% CI) of gastric cancer for selected gene-gene interaction analyses

From: Polymorphisms in metabolic genes, their combination and interaction with tobacco smoke and alcohol consumption and risk of gastric cancer: a case-control study in an Italian population

  

GSTT1

SULT1A1

  

Present

Null

Arg/Arg

His car.

NAT2

Fast

1*

1. 38 (0.63–3.01)

1*

1.45 (0. 71–2.95)

 

cases/controls

30/93

13/29

23/74

20/48

 

Slow

1.07 (0.61–1.88)

3.00 (1.52–5.93)

1.40 (0. 75–2.60)

2.00 (1.03–3.89)

 

cases/controls

36/103

26/28

35/81

29/50

  

p for interaction† = 0.17

p for interaction = 0.97

  

AP‡ = 52%

AP = 8%

SULT1A1

Arg/Arg

1*

1.53 (0.86–2.71)

-

-

 

cases/controls

35/122

22/34

  
 

His carriers

2.30 (1.18–4.45)

2.87 (1.36–6.05)

-

-

 

cases/controls

31/75

17/23

  
  

p for interaction = 0.70

  
  

AP = 1%

  
  1. * Reference category; † By likelihood ratio test; ‡ Attributable Proportion due to biological interaction (see methods)