| | |
Cases % (n)
|
Controls % (n)
|
OR (95% CI) * †
|
|---|
|
GSTM1 null
| |
56.2 (59)
|
52.7 (135)
|
1.13 (0.71–1.79)
|
|
GSTT1 null
| |
37.1 (39)
|
22.4 (57)
|
2.10 (1.27–3.44)
|
|
CYP1A1*2A
| |
20.5 (22)
|
22.0 (56)
|
0.88 (0.50–1.54)
|
|
CYP2E1*5
| |
4.7 (5)
|
7.8 (20)
|
0.54 (0.20–1.50)
|
|
CYP2E1*5A or *6
| |
14.5 (15)
|
10.6 (27)
|
1.33 (0.67–2.65)
|
|
NAT2 Slow ‡
| |
59.8 (64)
|
51.8 (131)
|
1. 38 (0.88–2.19)
|
|
SULT1A1
|
Arg/His
|
36.5 (39)
|
33.5 (85)
|
1.35 (0.82–2.21)
|
| |
His/His
|
10.3 (11)
|
5.1 (13)
|
2.46 (1.03–5.90)
|
|
EPHX1 exon 3
|
Tyr/His
|
38.7 (41)
|
36.0 (90)
|
1.24 (0.76–2.04)
|
| |
His/His
|
14.1 (15)
|
11.2 (28)
|
1.37 (0.67–2.80)
|
|
EPHX4 exon 4
|
His/Arg
|
30.5 (32)
|
37.4 (95)
|
0.77 (0.47–1.27)
|
| |
Arg/Arg
|
5.7 (6)
|
2.4 (6)
|
2.28 (0.70–7.20)
|
|
Imputed mEH phenotypes ^
|
Rapid
|
15.8 (15)
|
23.7 (59)
|
0.60 (0.30–1.15)
|
| |
Slow
|
25.3 (24)
|
21.2 (54)
|
1.00 (0.55–1.78)
|
| |
Very slow
|
8.4 (8)
|
8.6 (21)
|
0.82 (0.33–2.00)
|
- * OR adjusted for age and gender
- † Reference groups are the homozygous wild genotypes for each gene
- ‡ Reference group is fast acetylators (homo-heterozygous for the wild-type allele)
- ^ Reference group is the normal imputed phenotype
