Figure 5
IFN-gamma and the inhibition of NFκB suppress anoikis-induced psoriasin expression. 500 u of IFN-gamma suppresses the psoriasin expression induced by anoikis for 48 hours either by itself or in combination with dnIkkβ-virus in MCF10A cells. Neither infection with the different adenoviruses nor the IFN-gamma had any effect on the protein levels of pro-caspase-3. The function of the virus was verified by the accumulation of the IκBα protein. Tubulin assesses equal loading. C control.