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Table 5 EGFR haplotype frequencies in the cases and controls, and their association with lung cancer risk

From: Polymorphisms in the epidermal growth factor receptor gene and the risk of primary lung cancer: a case-control study

Haplotype Controls (n = 1164) Cases (n = 1164)
  no. (%) no. (%) Adjusted§ OR (95% CI) P
CGGCT 91 (7.8) 118 (10.1) 1.50 (1.09–2.07) 0.012*
CGGCC 124 (10.7) 110 (9.5) 1.08 (0.80–1.47) 0.60
CGGTT 350 (30.1) 305 (26.2) 1.00  
TAGCC 227 (19.5) 234 (20.1) 1.24 (0.97–1.58) 0.09
Others 372 (32.0) 397 (34.1) 1.24 (0.98–1.54) 0.07
Global P   0.08   
  1. The order of polymorphisms is as follows: 117378C>T, 142285G>A, 162093G>A, 181946C>T and 187114T>C.
  2. Twenty-five haplotypes that had a frequency of less than 5%.
  3. § Adjusted for age, gender and pack-years of smoking.
  4. * Bonferroni corrected P-value = 0.048.