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Table 4 Stratification analysis of the EGFR 181946C>T genotype frequencies in cases and controls

From: Polymorphisms in the epidermal growth factor receptor gene and the risk of primary lung cancer: a case-control study

Variable Genotype, no (%)    
  Cases Controls Adjusted OR (95% CI)
  CC + CT TT CC+TT TT CC+TT TT P
Smoking status        
   Never 91 (82.7) 19 (17.2) 114 (82.6) 24 (17.4) 1.0 0.89 (0.45–1.75) 0.73
   Ever 419 (88.8) 53 (11.2) 367 (82.7) 77 (17.3) 1.0 0.59 (0.41–0.86), * 0.007
   ≤ 38 pys 168 (88.4) 22 (11.6) 226 (84.0) 43 (16.0) 1.0 0.64 (0.37–1.12) 0.12
   > 38 pys 251 (89.0) 31 (11.0) 141 (80.6) 34 (19.4) 1.0 0.52 (0.30–0.88) 0.01
Histologic types§        
Squamous cell ca. 238 (88.1) 32 (11.9) 481 (82.6) 101 (17.4) 1.0 0.65 (0.41–1.01)  
Adenoca. 173 (84.4) 32 (15.6) 481 (82.6) 101 (17.4) 1.0 0.82 (0.52–1.28)  
Small cell ca. 90 (92.8) 7 (7.2) 481 (82.6) 101 (17.4) 1.0 0.32 (0.14–0.73)  
  1. Adjusted for age and pack-years of smoking.
  2. Current and former smoker.
  3. § Ten large cell carcinoma cases were excluded from this analysis.
  4. Adjusted for gender and pack-years of smoking.
  5. * P = 0.08, test for homogeneity test between genotype-related ORs of never- and ever-smokers.